Longitudinal Changes in Body Composition by Dual-energy Radiograph Absorptiometry Among Perinatally HIV-infected and HIV-uninfected Youth: Increased Risk of Adiposity Among HIV-infected Female Youth

The Pediatric Infectious Disease Journal
Tanvi S SharmaTracie L Miller

Abstract

Combination antiretroviral therapy has allowed youth with perinatal HIV infection (PHIV+) to live into adulthood, but many youth may experience metabolic and body composition changes that predispose to greater cardiovascular disease (CVD) risk. This longitudinal study evaluated changes in body composition measured by dual-energy radiograph absorptiometry (DXA) in a cohort of PHIV+ youth compared with HIV- controls over a 7-year period. PHIV+ youth and HIV- controls were prospectively enrolled in a single-site study to assess nutrition and CVD risk. Anthropometrics and DXA scans were longitudinally obtained to assess percent body fat and regional fat distribution. Using general linear models, we analyzed differences in body composition and anthropometric measures by sex between PHIV+ youth and controls over time. Two hundred thirty-five participants (156 PHIV+ and 79 HIV- controls) with at least 1 DXA performed since study enrollment were included for analysis. During the study period, 471 DXAs were obtained in the PHIV+ group and 95 in HIV- controls. PHIV+ females demonstrated greater increase in weight and body mass index over time compared with HIV- females, and significant increases in total percent body fat [estimate = 1.21...Continue Reading

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Citations

Feb 14, 2019·Journal of Neurovirology·Xiaotong QiaoYingying Ding
Oct 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Neil ThivalapillAlexander W Kay
Aug 18, 2020·Journal of Pediatric Gastroenterology and Nutrition·Junwei SuUNKNOWN CHANGES Bone Study Team
Oct 16, 2021·Current HIV/AIDS Reports·Sahera Dirajlal-Fargo, Grace A McComsey

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