Longitudinal changes in corneal curvature in keratoconus

Cornea
T T McMahonClek Study Group

Abstract

This study was designed to identify factors that predict longitudinal increases in corneal curvature as measured by the First Definite Apical Clearance Lens (FDACL) and flatter keratometric reading (Flat K) in keratoconus. The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study is a long-te rm evaluation of the natural history of keratoconus involving 1209 patients. This report uses 8 years of follow-up data from 1032 patients who had penetrating keratoplasty in neither eye at baseline and who provided enough data to compute the slope of the change with time in the FDACL or the Flat K. Outcome measures included the aforementioned slopes and whether the FDACL or the Flat K increased by 3.00 or more diopters (D) in at least 1 eye. At CLEK Study entry, patients were aged 38.9 +/- 10.8 years. Overall, 44.3% of them were women, and 69.3% of them were white. The slope of the change in FDACL (0.18 +/- 0.60 D/y) and Flat K (0.20 +/- 0.80 D) during 8 years translates into expected 8-year increases of 1.44 D in FDACL and 1.60 D in Flat K. Increases of > or = 3.00 D in either eye had an 8-year incidence of 24.8% for FDACL and 24.1% for Flat K. Independent predictors of increased FDACL included younger age, poorer baseline hi...Continue Reading

References

Apr 1, 1990·Ophthalmology·J H LassR H Keates
Sep 1, 1969·American Journal of Optometry and Archives of American Academy of Optometry·T F Brungardt
Mar 1, 1994·Ophthalmology·S J TuftR J Buckley
Nov 1, 1995·Optometry and Vision Science : Official Publication of the American Academy of Optometry·M YounesH Bedell
Dec 24, 1997·Optometry and Vision Science : Official Publication of the American Academy of Optometry·M K Smolek, S D Klyce
Oct 21, 1998·Optometry and Vision Science : Official Publication of the American Academy of Optometry·M Jeandervin, J Barr
Sep 28, 2002·Cornea·Karla ZadnikUNKNOWN CLEK Study Group. Collaborative Longitudinal Evaluation of Keratoconus
Mar 17, 2004·Ophthalmology·Xiaohui LiHuiying Yang
Jul 21, 2004·Eye & Contact Lens·Javier González PérezE Yebra-Pimentel
Feb 1, 1946·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·M AMSLER

❮ Previous
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Citations

Jul 8, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A HoyerL E Pillunat
Jun 14, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·P Maier, T Reinhard
Mar 10, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jose Luis MatoElío Díez-Feijoo
Nov 10, 2012·International Ophthalmology·Seyed Mahdi Ahmadi HosseiniChandramalar T Santhirathelagan
Jan 30, 2008·American Journal of Ophthalmology·Steven M KymesUNKNOWN Collaborative Longitudinal Evaluation of Keratoconus Study Group
Dec 22, 2012·Eye·D M GoreB D Allan
Apr 25, 2008·Cornea·Ashraf M MahmoudUNKNOWN CLEK Study Group
Feb 9, 2012·Cornea·Yee Onn KokSeng Chee Loon
Jun 29, 2013·Cornea·George D KymionisIoannis G Pallikaris
Oct 4, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Barbara FinkJoseph T Barr
Aug 6, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Seyed Mahdi Ahmadi HosseiniMohammad Reza Sedaghat
Jun 6, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Srujana SahebjadaPaul N Baird
Oct 17, 2014·Eye & Contact Lens·Sarah E BrownPenny A Asbell
Dec 24, 2010·Eye & Contact Lens·Benjamin J Ernst, Hugo Y Hsu
Jul 31, 2013·Journal of Cataract and Refractive Surgery·Steven A Greenstein, Peter S Hersh
Feb 5, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Fereshteh AbolbashariShamala Retnasabapathy
Jul 9, 2010·Journal of Cataract and Refractive Surgery·Illés KovácsZoltán Z Nagy
Nov 10, 2009·Ophthalmology·Kata MiháltzZoltán Z Nagy
Jun 15, 2011·Journal of Refractive Surgery·Martha JaimesAlejandro Navas
Jul 29, 2008·Journal of Cataract and Refractive Surgery·Afsun SahinHikmet Basmak
May 13, 2008·Journal of Cataract and Refractive Surgery·Frederik Raiskup-WolfLutz E Pillunat
May 8, 2007·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·H WagnerK Zadnik
May 20, 2015·Survey of Ophthalmology·J Bradley RandlemanFarhad Hafezi
Aug 4, 2015·The Ocular Surface·Robert P L WisseAllegonda Van der Lelij
Feb 19, 2013·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Richard G LindsayGrant R Snibson
Oct 23, 2015·BioMed Research International·Hala El RamiElias Jarade
Jun 11, 2015·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Lisa McAnena, Michael O'Keefe
Apr 4, 2015·Journal of Cataract and Refractive Surgery·Mohammed ZiaeiUNKNOWN ASCRS Cornea Clinical Committee
Aug 20, 2014·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A TheuringF Raiskup
Aug 18, 2010·Korean Journal of Ophthalmology : KJO·Joon Seo HwangMee Kum Kim
Jun 5, 2013·Korean Journal of Ophthalmology : KJO·Seong Joon AhnWon Ryang Wee
Jun 3, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S J LangT Reinhard
Sep 1, 2016·Journal of Current Ophthalmology·Farideh SharifipourBahman Cheraghian
Sep 30, 2016·Acta Ophthalmologica·Lisa McAnenaMichael O'Keefe
Oct 31, 2016·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Alexander HamiltonSusmito Biswas
Feb 12, 2017·Journal of Lipid Research·Hui QiDimitrios Karamichos
Oct 13, 2016·The British Journal of Ophthalmology·Akilesh GokulCharles N J McGhee

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