PMID: 9553789Apr 29, 1998Paper

Longitudinal changes in inflammatory markers in nasal lavage of cotton workers. Relation to endotoxin exposure and lung function changes

International Archives of Occupational and Environmental Health
S KemanP J Borm

Abstract

The aim of this study was to evaluate time-related changes in inflammatory markers in nasal lavage (NAL) in relation to endotoxin exposure and lung function changes. Endotoxin in cotton dust is well known to elicit proinflammatory mediators involved in acute or chronic respiratory inflammation due to cotton dust. We applied nasal lavage as well as lung function and exposure measurements in a small group (n = 11) of cotton workers during 6 weeks of observation (after 2 weeks free of exposure). Several inflammatory markers in NAL, such as interleukin 8 (IL-8), IL-6, and down-stream mediators, including soluble tumor necrosis factor receptor 75 (sTNF-R75) and soluble intercellular adhesion molecule 1 (ICAM-1), cell counts, marker of epithelial response (uric acid), and marker of plasma exudation (albumin) were measured. At the exposure levels examined in this study [cotton dust, geometric mean (GM) = 1.10 mg/m3; endotoxin, GM = 2,869 EU/m3], several inflammatory markers in NAL such as IL-8, sTNF-R75, and albumin tended to increase through the measurement period with increasing airborne endotoxin concentration (in six workers who had paired measurements in weeks 1 and 6). Although no statistical significance was reached, airborne e...Continue Reading

Citations

Oct 30, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Romy SethSusan M Tarlo
Jan 1, 2003·Environmental Health and Preventive Medicine·Vicki StoneKenneth Donaldson
Nov 19, 2011·Scandinavian Journal of Medicine & Science in Sports·E C GomesV Stone
Jun 6, 2015·International Forum of Allergy & Rhinology·Claudia StaffieriMaria Luisa Scapellato
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·J H ParkD K Milton
Jul 8, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Angelico MendyGilbert Ramirez
Jan 27, 2011·European Journal of Applied Physiology·Elisa Couto GomesGeraint Florida-James
Jan 1, 2000·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·P J BormR P Schins
Apr 21, 2020·Archives of Environmental & Occupational Health·Yifokire TeferaMagne Bråtveit
Jun 19, 2004·Journal of Occupational and Environmental Hygiene·Hanna PaananenKirsi Luoto
Jan 24, 2003·Human & Experimental Toxicology·M AmeenQ Rahman
Dec 24, 2010·The Annals of Occupational Hygiene·Priyamvada PaudyalJonathan G Ayres
Nov 26, 2010·The Journal of Allergy and Clinical Immunology·Romy SethSusan M Tarlo

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