Longitudinal changes in maternal serum 1,25-dihydroxyvitamin D and insulin like growth factor I levels in pregnant women who developed preeclampsia: comparison with normotensive pregnant women

The Journal of Steroid Biochemistry and Molecular Biology
Ali HalhaliFernando Larrea

Abstract

This study was undertaken to determine the longitudinal changes of serum 1,25-dihydroxyvitamin D (1,25-(OH)(2)D) and insulin like growth factor I (IGF-I) levels at 20.7, 27.6, and 35.5 week periods of gestation in 40 pregnant women who remained normotensive (NT) and in 10 women who developed preeclampsia (PE). As compared with the first period, significant increases (P < 0.01) in maternal serum 1,25-(OH)(2)D and IGF-I were observed in the NT group. In the PE group, a similar increase in serum 1,25-(OH)(2)D was observed. In contrast, significant (P < 0.05) lower IGF-I levels were observed in the PE group at the moment of diagnosis. In addition a high incidence of subjects with low increase in IGF-I levels (<percentile 10) was found in the PE group (30% versus 5%, P = 0.02). In conclusion, circulating levels of 1,25-(OH)(2)D were not alterated in women before they developed PE. In the opposite, the high percentage of PE women with low increase in circulating IGF-I levels between the 20th and 35th week of pregnancy suggests early alterations of IGF-I synthesis in women developing PE.

References

Jun 1, 1992·The Journal of Clinical Endocrinology and Metabolism·E W SeelyS W Graves
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
Dec 31, 1997·Endocrine Reviews·C S Kovacs, H M Kronenberg
Jul 28, 1999·Molecular Human Reproduction·A HalhaliF Larrea
Apr 25, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·S Handwerger, M Freemark
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·M SowersM Jannausch

❮ Previous
Next ❯

Citations

Aug 17, 2012·Nutrition Research Reviews·Hanna OlaussonAnn Prentice
Jul 16, 2011·Annual Review of Nutrition·Patsy M Brannon, Mary Frances Picciano
Aug 31, 2012·American Journal of Physiology. Cell Physiology·M GrundmannF von Versen-Höynck
Jul 23, 2008·Annals of Nutrition & Metabolism·Margaretha HaugenHelle Margrete Meltzer
Jan 24, 2008·Reproductive Biology and Endocrinology : RB&E·David BarreraLorenza Díaz
Nov 4, 2011·Reproductive Biology and Endocrinology : RB&E·Magdalena Grundmann, Frauke von Versen-Höynck
May 19, 2012·Endocrine Reviews·Clifford J RosenChristopher S Kovacs
Jan 27, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Ali HalhaliFernando Larrea
Apr 3, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·S Q WeiW D Fraser
Aug 30, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·C BertiI Cetin
Jun 7, 2018·Biomédica : revista del Instituto Nacional de Salud·Norma Cecilia Serrano-DíazDoris Cristina Quintero-Lesmes
May 9, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Faustino R Pérez-López
Mar 31, 2015·Clinical Hemorheology and Microcirculation·Georg-Friedrich von TempelhoffRoland Csorba
May 21, 2020·Nutrients·Bianca Schröder-HeurichFrauke von Versen-Höynck
May 26, 2017·PloS One·Lars BrodowskiFrauke von Versen-Höynck
Aug 11, 2020·Journal of Endocrinological Investigation·B A Ryan, C S Kovacs
Jul 16, 2017·BMC Pregnancy and Childbirth·Juhi M PurswaniSaurabh Mehta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.