Longitudinal changes in ultrasound measurements: a parallel study in subjects with genetic disorders and healthy controls

Ultrasound in Medicine & Biology
Z HalabaW Pluskiewicz

Abstract

Disturbances in skeletal status in subjects with genetic disorder may increase their fracture risk. The aim of the study was longitudinal observation of phalangeal speed of sound changes across the bone over a period of 2 y in 24 patients (14 boys and 10 girls, mean age 9.63 +/- 1.8 y.) and 24 age-matched healthy controls (14 boys and 10 girls, mean age 9.65 +/- 1.71 y.). Weight and height did not differ between patients and controls at baseline and follow-up. Patients with the following disorders were evaluated: 7 with Down syndrome, 6 nonspecific mental retardations of unknown etiology, 5 Martin-Bell syndrome and 6 with other diseases. In patients and controls, no factors potentially influencing bone metabolism (except for genetic disorder) were present. Bone status was assessed by quantitative ultrasound at hand phalanges using DBM Sonic 1200 (IGEA, Carpi, Italy), which measures amplitude-dependent speed of sound (Ad-SoS [m/s]). At baseline, Ad-SoS and Z-score were significantly lower in patients than in controls (1892 +/- 51 m/s versus 1936 +/- 43 m/s, p < 0.01 and -1.47 +/- 1.43 versus -0.14 +/- 1.04, p < 0.001, respectively. In follow-up, Ad-SoS and Z-score increased significantly in patients (1892 +/- 51 m/s to 1934 +/- ...Continue Reading

References

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Citations

Oct 23, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A González-AgüeroJ A Casajús
Jul 9, 2010·Radiologic Clinics of North America·Giuseppe GuglielmiWilfred C G Peh
Aug 5, 2009·European Journal of Radiology·Giuseppe Guglielmi, Francesca de Terlizzi
Mar 14, 2012·Developmental Medicine and Child Neurology·Alejandro González-AgüeroJosé A Casajús
Jul 16, 2014·Ultrasound in Medicine & Biology·A C KokG J M Tuijthof
May 1, 2012·Ultrasound in Medicine & Biology·Agata P ChobotWojciech Pluskiewicz

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