Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory

Frontiers in Aging Neuroscience
Marcelo FeboThomas C Foster

Abstract

The current longitudinal study examined factors (sex, physical function, response to novelty, ability to adapt to a shift in light/dark cycle, brain connectivity), which might predict the emergence of impaired memory during aging. Male and female Fisher 344 rats were tested at 6, 12, and 18 months of age. Impaired spatial memory developed in middle-age (12 months), particularly in males, and the propensity for impairment increased with advanced age. A reduced response to novelty was observed over the course of aging, which is inconsistent with cross-sectional studies. This divergence likely resulted from differences in the history of environmental enrichment/impoverishment for cross-sectional and longitudinal studies. Animals that exhibited lower level exploration of the inner region on the open field test exhibited better memory at 12 months. Furthermore, males that exhibited a longer latency to enter a novel environment at 6 months, exhibited better memory at 12 months. For females, memory at 12 months was correlated with the ability to behaviorally adapt to a shift in light/dark cycle. Functional magnetic resonance imaging of the brain, conducted at 12 months, indicated that the decline in memory was associated with altered ...Continue Reading

References

Aug 1, 1976·Journal of Comparative and Physiological Psychology·R T Gentry, G N Wade
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P V PiazzaH Simon
Nov 1, 1989·Neurobiology of Aging·M Gallagher, R D Burwell
Feb 1, 1973·Physiology & Behavior·A A GerallU C Cooper
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Jun 12, 1998·Nature·D J Watts, S H Strogatz
Apr 7, 1999·Neurobiology of Aging·G Winocur
Aug 24, 1999·Neuroscience Letters·N V LukoyanovM M Paula-Barbosa
Jun 7, 2000·Chronobiology International·D Weinert
Jul 12, 2002·Behavioural Brain Research·Pawel Boguszewski, Jolanta Zagrodzka
Aug 21, 2002·Stress : the International Journal on the Biology of Stress·Victoria Luine
Oct 19, 2002·Behavioural Brain Research·Thomas van GroenJ Michael Wyss
May 23, 2003·Developmental Psychology·Deborah FinkelNancy L Pedersen
Mar 12, 2004·Neurobiology of Aging·F Dellu-HagedornH Simon
May 26, 2004·Brain Research. Developmental Brain Research·Kim G C HellemansMary C Olmstead
Aug 18, 2004·Neurobiology of Aging·Helen R SabolekJames J Chrobak
Apr 28, 2005·Experimental Brain Research·Meritxell Torras-GarciaIsabel Portell-Cortés
Jun 18, 2005·Neurobiology of Aging·An-Tao DuMichael W Weiner
Aug 5, 2006·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Julie E YonkerAgneta Herlitz
Sep 15, 2006·Behavioural Brain Research·Cosette FoxCatherine Harrison
Mar 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jari SaramäkiJános Kertész
May 12, 2007·Neurobiology of Learning and Memory·Rodrigue GalaniJean-Christophe Cassel
Aug 7, 2007·Physiology & Behavior·Mikael AltunBrun Ulfhake
Nov 3, 2007·Neurobiology of Aging·Li CuiThomas C Foster
Nov 27, 2007·Behavioural Brain Research·K AntoniouZ Papadopoulou-Daifoti
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Jan 1, 1992·Archives of Gerontology and Geriatrics·M GygerY Guigoz
Oct 9, 2009·Nature Reviews. Neuroscience·Seralynne D VannEleanor A Maguire

❮ Previous
Next ❯

Citations

Feb 9, 2021·Frontiers in Aging Neuroscience·Joseph A McQuailThomas C Foster
Mar 8, 2021·Behavioural Brain Research·William H GendronRichard E Brown
Sep 8, 2021·The European Journal of Neuroscience·Sophia HaberstumpfMartin J Herrmann

❮ Previous
Next ❯

Software Mentioned

EthoVision XT
MATLAB
Brain Connectivity Toolbox for MATLAB
Brain
FLIRT
ClockLab
Analysis of Functional NeuroImages ( AFNI
VnmrJ
MathWorks
FMRIB Library

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Related Papers

Neuroscience and Biobehavioral Reviews
Christine BastinEmmanuel J Barbeau
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
Martin LepagePhilippe-Olivier Harvey
Proceedings of the National Academy of Sciences of the United States of America
K HenkeA Buck
© 2021 Meta ULC. All rights reserved