Longitudinal characterization of CD4, CD8 T-cell subsets and of haematological parameters in healthy newborns of cynomolgus monkeys

Veterinary Immunology and Immunopathology
Silvia BaroncelliP Verani

Abstract

A longitudinal characterization of immune cell subpopulations (lymphocytes, CD4+ and CD8+ cells), of routine haematological parameters and of immunoglobulin serum levels was carried out in newborn Macaca fascicularis starting from 1 week up to 1 year of life. In neonates, the percentage of CD4+ lymphocytes is almost double, while the percentage of CD8+ cells is lower than that found in adult monkeys (> 5-years old). An inverted trend in the percentage of the two T-lymphocyte subpopulations was observed during the weeks following birth, with a progressive increase of circulating CD8+, paralleled by a decrease of CD4+ cell number. Consequently, the CD4/CD8 ratio slowly decreases, even if, at 12 months of life, it is still higher than that found in adult animals. Several differences were also noted between young and adult monkeys with regard to the total number of circulating CD4+ and CD8+ cells. Haematological parameters did not show consistent differences with respect to adult values. The plasma IgG level is high at birth, then decreases until 6 months of life, while the IgM and IgA values are very low during the first weeks of life but increase in the following period. Our data showed that variations of immunological (CD4+, CD8...Continue Reading

References

Aug 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D KarrerP G Turillazzi
Feb 1, 1992·Acta Paediatrica·J HeldrupK Prellner
Dec 1, 1988·Current Opinion in Immunology·J Cambier
May 1, 1971·Acta paediatrica Scandinavica·Y MatothI Varsano
Jun 1, 1993·Veterinary Immunology and Immunopathology·M R BleavinsF A de la Iglesia

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