Longitudinal decline in lung function among older construction workers

Occupational and Environmental Medicine
John DementPatricia Quinn

Abstract

Occupational exposures to vapours, gasses, dusts and fumes (VGDF) and chest X-ray abnormalities by the International Labour Office (ILO) classification system are associated with reduced lung function, with the majority of published studies being cross-sectional. We examined the effects of VGDF exposures, as well as ILO parenchymal changes, pleural plaque and diffuse pleural thickening (DPT) on reduction in lung function in a longitudinal study. Chest radiographs and spirometry for 3150 ageing construction workers enrolled in a medical screening programme with a baseline and at least one follow-up examination were studied. Indices for VGDF exposure, parenchymal changes, pleural plaque and DPT severity were developed and used in longitudinal mixed models of lung function. Smoking and VGDF exposure were associated with decreased FEV1 and FVC at baseline as well as accelerated rates of annual decline. High VGDF exposure was associated with a yearly decline of -19.5 mL for FEV1 and -15.7 mL for FVC. Parenchymal abnormalities, pleural plaque and DPT were more strongly associated with reduced FVC. An increase of one unit in the pleural plaque severity index resulted in approximately -5.3 mL loss of FVC and -3.3 mL loss of FEV1, with ...Continue Reading

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Citations

Jan 31, 2020·Occupational and Environmental Medicine·John M DementPatricia Quinn
Nov 2, 2019·International Journal of Environmental Research and Public Health·Rosemary K SokasChris Trahan Cain
Nov 24, 2020·The Science of the Total Environment·Khusniddin KhamraevJae-Ho Choi
Mar 18, 2021·American Journal of Industrial Medicine·John M DementStella Hines

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