Longitudinal degeneration of the basal forebrain predicts subsequent dementia in Parkinson's disease.

Neurobiology of Disease
Joana B PereiraOskar Hansson

Abstract

Cholinergic dysfunction plays a prominent role in cognitive impairment in Parkinson's disease (PD). The aim of this study was to assess the relationship of baseline and longitudinal basal forebrain atrophy with cognitive decline and dementia in PD. We included 106 non-demented PD patients, 19 PD dementia (PDD) patients and 42 controls with longitudinal structural MRI and cognitive testing. After 4.2 ± 1.8 years, 20 non-demented PD patients were diagnosed with dementia (PD-dementia converters), whereas the rest of PD patients remained non-demented (stable-PD). We compared MRI volumes of the medial septum/diagonal band (Ch1/Ch2) and nucleus basalis of Meynert (Ch4) between groups. Cox regression analyses were applied to test whether Ch1/Ch2 or Ch4 atrophy could predict future dementia and linear mixed models assessed their association with cognitive decline. Compared to controls, we found reduced Ch4 baseline volumes in PD-dementia converters (p = .003) and those who already had PDD (p < .001) but not in stable-PD. Over time, there was a greater loss in Ch1/Ch2 volumes in PD-dementia converters and PDD compared to the other groups (p = .004). Baseline and longitudinal Ch4 volumes were associated with cognition (p < .002) and long...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Nov 1, 1984·The American Journal of Psychiatry·W G RosenK L Davis
Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Oct 14, 2004·Journal of Neural Transmission·J L W BosboomE Ch Wolters
May 31, 2007·Brain : a Journal of Neurology·C H Williams-GrayR A Barker
Dec 22, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Bruno DuboisMurat Emre
Jul 8, 2008·Parkinsonism & Related Disorders·M E KalaitzakisS M Gentleman
Oct 9, 2009·Brain : a Journal of Neurology·Caroline H Williams-GrayRoger A Barker
Oct 17, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Rolf SebaldtBenedicte Lescrauwaet
Jan 11, 2011·NeuroImage·John Ashburner, Karl J Friston
May 10, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicolaas I BohnenKirk A Frey
Jun 20, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Caroline H Williams-GrayRoger A Barker
Feb 8, 2014·Journal of Alzheimer's Disease : JAD·Ingo KilimannStefan J Teipel
Apr 19, 2015·Brain : a Journal of Neurology·James GratwickeThomas Foltynie
Dec 12, 2017·Brain : a Journal of Neurology·Nicola J RayMichel J Grothe
Jan 13, 2018·Brain : a Journal of Neurology·James P Gratwicke, Thomas Foltynie
Dec 12, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Fatma GargouriStéphane Lehéricy
Jun 9, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Matthew J BarrettT Jason Druzgal

❮ Previous
Next ❯

Citations

Jan 1, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Joanna WilsonLynn Rochester
Nov 22, 2020·Journal of Neurochemistry·Christine N Metz, Valentin A Pavlov
Feb 28, 2021·Journal of Neurochemistry·Katarzyna WinekAndreas Meisel
Mar 30, 2021·Current Behavioral Neuroscience Reports·Chesney E CraigNicolaas I Bohnen
Jul 3, 2021·Nature Reviews. Disease Primers·Dag AarslandDaniel Weintraub
Aug 5, 2021·Parkinsonism & Related Disorders·Matthew J BarrettT Jason Druzgal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Naroa Ibarretxe-BilbaoMaría-José Martí
Dementia and Geriatric Cognitive Disorders
David K Johnson, James E Galvin
© 2021 Meta ULC. All rights reserved