Longitudinal determinants of bronchial responsiveness to inhaled histamine

Chest
C S Ulrik, V Backer

Abstract

The point prevalence of bronchial hyperresponsiveness (BHR) is imperfectly associated with current asthma, possibly due to changes over time in bronchial responsiveness (BR). To evaluate cross-sectional and longitudinal determinants of BR, a population sample comprising 408 children and adolescents, aged 7 to 17 years at enrollment, was examined twice, 6 years apart. Case history was obtained by interview and questionnaire. BR to inhaled histamine, pulmonary function, and skin prick test reactivity were measured using standard techniques. The point prevalence of BHR (the concentration of histamine causing a 20% decline in FEV1 <8 mg/mL) declined from childhood to early adulthood (25% and 6%, respectively; p<0.001); and similarly a decline in histamine dose-response slope was observed. At both surveys, prechallenge FEV1 percent predicted, asthma, and atopy, especially atopy to house dust mite (HDM), were important determinants for the degree of BR. After adjustment for prechallenge FEV1 percent predicted, no male-female difference was observed in degree of BR. Lower FEV1 percent predicted (p=0.003), asthma (p<0.001), higher degree of BR (p=0.003), and atopy to HDM (p=0.007) at enrollment predicted a higher degree of BR at the se...Continue Reading

References

May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Sep 1, 1990·The American Review of Respiratory Disease·D W Cockcroft, F E Hargreave
Sep 1, 1990·The American Review of Respiratory Disease·P K PattemoreA W Stewart
Jan 1, 1990·The American Review of Respiratory Disease·R J HoppN M Nair
Dec 1, 1987·The American Review of Respiratory Disease·G O'ConnorS Weiss
Apr 1, 1988·The American Review of Respiratory Disease·B RijckenR van der Lende
Aug 1, 1984·The Journal of Allergy and Clinical Immunology·R J HoppR G Townley
Jan 1, 1995·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C S Ulrik
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·J K PeatA J Woolcock
Sep 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C S Ulrik
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·J K PeatW Xuan
Oct 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J K PeatA J Woolcock

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Citations

May 23, 2007·Thorax·Talat IslamFrank D Gilliland
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·N N BahcecilerI B Barlan
Sep 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R NickelUNKNOWN German Multicenter Allergy Study Group
Apr 19, 2008·American Journal of Respiratory and Critical Care Medicine·Kelan G TantisiraUNKNOWN Childhood Asthma Management Program Research Group
Oct 31, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Koray HarmanciIpek Turktas
Jan 1, 2009·Expert Review of Clinical Immunology·Padmaja SubbaraoMalcolm R Sears
Apr 18, 2002·Allergologia et immunopathologia·F GürkanK Haspolat
Apr 19, 2011·The Journal of Allergy and Clinical Immunology·Rachel A CollinsPeter D Sly
Oct 22, 2011·Respiratory Medicine·Amund RiiserKarin Lødrup Carlsen

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