Longitudinal differences in aerobic capacity between children with sickle cell anemia and matched controls

Pediatric Blood & Cancer
Andrew M WatsonMaciej S Buchowski

Abstract

The purpose of this study was to compare longitudinal trajectories of maximal aerobic capacity in children with sickle cell anemia (SCA) and matched healthy controls, and explore whether these trajectories were associated with selected physiologic variables. Children with SCA (n = 33) and healthy controls (n = 30) matched at baseline for race, sex, Tanner stage, height, and weight completed three consecutive annual fitness assessments (VO2peak ). Data were compared between the groups at each time point and within groups over time. Change in VO2peak between the two groups over time was assessed using a linear mixed model with age, sex, fat-free mass (FFM), Tanner stage, and hemoglobin (Hgb) concentration as covariates. At baseline, children with SCA had significantly lower Hgb concentration (8.9 vs. 13.7 g/dL, P < 0.001) and relative VO2peak (24.2 vs. 27.9 ml/kg/min, P = 0.006) than healthy controls. Over time, children with SCA had smaller increases than healthy controls in VO2peak (-0.1 and +4.9 ml/kg/min, P < 0.001), Tanner stage at year 2 (15% and 66% Tanner 4, P < 0.001), and FFM (+4.0 and +6.8 kg, P = 0.02). Changes in Hgb concentration did not differ between groups (+0.03 and +0.09 g/dL, P = 1.0). After adjusting for age,...Continue Reading

References

Jan 14, 1977·European Journal of Applied Physiology and Occupational Physiology·K Yamaji, M Miyashita
Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA L Coates
Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA L Coates
Jan 1, 1971·Acta Paediatrica Scandinavica. Supplement·L Hermansen, S Oseid
Nov 1, 1984·American Journal of Diseases of Children·B S AlpertW Covitz
Jan 30, 2002·The Journal of Pediatrics·Maciej S BuchowskiKong Y Chen
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Leigh A CallahanBernard Gutin
Jun 26, 2002·The American Journal of Clinical Nutrition·Elizabeth M BardenBabette S Zemel
Nov 27, 2002·The American Journal of Clinical Nutrition·Maciej S BuchowskiWinfred C Wang
Sep 9, 2004·Medicine and Science in Sports and Exercise·Christina A GeithnerGaston P Beunen
Jan 10, 2006·Clinical Physiology and Functional Imaging·James A DavisPatrick H Pham
Oct 7, 2006·European Journal of Applied Physiology·Magnus DenckerLars Bo Andersen
Jul 17, 2007·The American Journal of the Medical Sciences·Victor A Convertino
Jun 23, 2009·Pediatric Blood & Cancer·Melissa RhodesMaciej S Buchowski
Dec 7, 2010·Lancet·David C ReesMark T Gladwin
Aug 27, 2011·Autonomic Neuroscience : Basic & Clinical·Wolney de Andrade MartinsCharles Mady
Oct 14, 2011·American Journal of Preventive Medicine·Joey C EisenmannGregory J Welk
Mar 24, 2012·Journal of the American College of Cardiology·Mark T Gladwin, Vandana Sachdev
Aug 28, 2012·Chest·Rifat A ChaudrySuzanne Crowley
May 7, 2014·American Journal of Hematology·Eduard J van BeersPaul Bresser

Citations

Jan 27, 2017·Children·Paolo T PianosiHan C G Kemper
Apr 28, 2019·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Suzanne AmeringerEdmund O Acevedo
May 22, 2018·Pediatric Blood & Cancer·Tarek AlsaiedMichael D Taylor

Related Concepts

Hemoglobin B
Anemia, Sickle Cell
Eryhem
Dioxygen
Puberty
Anemia, Sickle Cell
Hemoglobin
Puberty
Racial Group
Longitudinal

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.