Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease

Parkinsonism & Related Disorders
Michael J FirbankJ T O'Brien

Abstract

Changes in the white matter of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) have been reported using diffusion weighted MRI, though few longitudinal studies have been done. We performed diffusion weighted MRI twice, a year apart on 23 AD, 14 DLB, and 32 healthy control subjects. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated. In AD, there were widespread regions where the longitudinal MD increase was greater than in controls, and small areas in the parietal and temporal lobes where it was greater in AD than DLB. In AD, decrease in brain volume correlated with increased MD. There were no significant differences in progression between DLB and controls. In AD the white matter continues to degenerate during the disease process, whereas in DLB, changes in the white matter structure are a relatively early feature. Different mechanisms are likely to underpin changes in diffusivity.

References

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Citations

Apr 2, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Derek DustinRobia G Pautler
Aug 19, 2018·Journal of Neurology·Avinash ChandraUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 15, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·L BonanniUNKNOWN DLB-SINdem study group
May 11, 2018·Current Opinion in Neurology·Massimo Filippi, Federica Agosta
Nov 17, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Federica AgostaMassimo Filippi
Feb 8, 2020·NeuroImage. Clinical·Nicolas NicastroJohn T O'Brien
Apr 2, 2021·Brain and Behavior·Kyoungwon BaikByoung Seok Ye
Dec 13, 2018·Progress in Nuclear Magnetic Resonance Spectroscopy·Andrew M Blamire

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