Longitudinal effects of aging on plasma proteins levels in older adults - associations with kidney function and hemoglobin levels

PloS One
Lars LindErik Ingelsson

Abstract

A targeted proteomics chip has been shown to be useful to discover novel associations of proteins with cardiovascular disease. We investigated how these proteins change with aging, and whether this change is related to a decline in kidney function, or to a change in hemoglobin levels. In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, including 1,016 participants from the general population aged 70 at baseline, 84 proteins were measured at ages 70, 75, 80. At these occasions, glomerular filtration rate (eGFR) was estimated and the hemoglobin levels were measured. Sixty-one of the 84 evaluated proteins changed significantly during the 10-year follow-up (multiple testing-adjusted alpha = 0.00059), most showing an increase. The change in eGFR was inversely related to changes of protein levels for the vast majority of proteins (74%). The change in hemoglobin was significantly related to the change in 40% of the evaluated proteins, with no obvious preference of the direction of these relationships. The majority of evaluated proteins increased with aging in adults. Therefore, normal ranges for proteins might be given in age-strata. The increase in protein levels was associated with the degree of red...Continue Reading

References

Sep 17, 2008·BMC Medical Genomics·Susann SchenkMatthias Mann
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Axel C CarlssonJohan Ärnlöv
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Dec 28, 2017·Proteomics. Clinical Applications·Anders ChristenssonSteve A Williams

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Citations

Dec 3, 2020·International Journal of Molecular Sciences·Daniele CapitanioCecilia Gelfi
Mar 18, 2021·Aging Cell·Ruin MoaddelLuigi Ferrucci
Jun 8, 2021·Journal of the American Heart Association·Lars LindJohan Sundström
Aug 31, 2021·Journal of Alzheimer's Disease : JAD·Alex HandyUNKNOWN AddNeuroMed, and the GERAD1 Consortium

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Methods Mentioned

BETA
protein array
PCR
chip

Software Mentioned

STATA14
PIVUS

Related Concepts

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