PMID: 9165344May 1, 1997Paper

Longitudinal endolymph flow associated with acute volume increase in the guinea pig cochlea

Hearing Research
A N Salt, J DeMott

Abstract

Endolymph volume disturbances were induced by microinjections of artificial endolymph into the second turn of the guinea pig cochlea at rates less than 60 nl/min. Induced longitudinal movements and area changes of endolymph were quantified in the basal turn using an ionic flow marker technique. Tetramethylammonium (TMA) was used as a flow marker by iontophoresing it into endolymph in micromolar amounts. TMA movements in the apical and basal directions were monitored by ion-selective electrodes. Changes in endolymph flow and cross-sectional area of scala media were derived using a mathematical model to interpret the recorded tracer time courses. The model was validated by performing comparable volume injections and flow measurements in fine-diameter plastic tubes. The rate of flow of endolymph measured prior to injection was close to zero, in agreement with prior studies. Based on the injection of different volumes into endolymph over a 15 min period, we found that injection of up to 80 nl of artificial endolymph into the second turn would not induce flow in the basal turn. However, above this amount, flow towards the base increased at a rate which correlated with the injected volume, with endolymph moving basally by a distance ...Continue Reading

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Citations

Sep 11, 2004·Journal of the Association for Research in Otolaryngology : JARO·Alec N Salt
Jun 27, 2002·Journal of the Association for Research in Otolaryngology : JARO·A YamauchiS M Highstein
Jan 16, 2003·Hearing Research·Mueed AhmadGary W Harding
Sep 24, 1998·Hearing Research·A N Salt, J E DeMott
Mar 19, 1999·Hearing Research·R WuM Nagura
Oct 17, 2002·Journal of the Association for Research in Otolaryngology : JARO·R A SchmiedtB A Schulte
Dec 29, 2005·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·W L ValkF W J Albers
Jun 27, 2012·Molecular Aspects of Medicine·Andreas EckhardHubert Löwenheim
Jul 26, 2015·Pflügers Archiv : European journal of physiology·A EckhardH Löwenheim
May 10, 2003·Acta Oto-laryngologica·Tamotsu TakeshitaTomoyuki Hoshino
Jun 25, 1999·Acta Oto-laryngologica·R Thalmann, I Thalmann
Apr 3, 2004·The Journal of the Acoustical Society of America·Davud B SirjaniShane A Hale
Aug 27, 1999·The Journal of the Acoustical Society of America·A N Salt, J E DeMott
Aug 29, 2018·The Journal of Laryngology and Otology·J Hornibrook
Sep 16, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Gail IshiyamaAkira Ishiyama
Jun 9, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joseph B Nadol
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V CouloignerE Ferrary
Nov 17, 2001·Annals of the New York Academy of Sciences·A N Salt
Jul 1, 2004·Acta Oto-laryngologica·Vincent CouloignerEvelyne Ferrary
Mar 25, 2008·The Annals of Otology, Rhinology, and Laryngology·Vincent CouloignerEvelyne Ferrary
Oct 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryuhei InamotoNozomu Mori
Mar 16, 2021·Vestnik otorinolaringologii·M A KutlubaevM V Zamergrad
Jan 2, 2009·International Journal of Pediatric Otorhinolaryngology·Chul Ho JangIl Yong Park
Nov 13, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jeremy HornibrookChristopher M Smith

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