Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries

Malaria Journal
Chris DrakeleyEdith Roset Bahmanyar

Abstract

Plasmodium falciparum prevalence (PfPR) is a widely used metric for assessing malaria transmission intensity. This study was carried out concurrently with the RTS,S/AS01 candidate malaria vaccine Phase III trial and estimated PfPR over ≤ 4 standardized cross-sectional surveys. This epidemiology study (NCT01190202) was conducted in 8 sites from 6 countries (Burkina Faso, Gabon, Ghana, Kenya, Malawi, and Tanzania), between March 2011 and December 2013. Participants were enrolled in a 2:1:1 ratio according to age category: 6 months-4 years, 5-19 years, and ≥ 20 years, respectively, per year and per centre. All sites carried out surveys 1-3 while survey 4 was conducted only in 3 sites. Surveys were usually performed during the peak malaria parasite transmission season, in one home visit, when medical history and malaria risk factors/prevention measures were collected, and a blood sample taken for rapid diagnostic test, microscopy, and haemoglobin measurement. PfPR was estimated by site and age category. Overall, 6401 (survey 1), 6411 (survey 2), 6400 (survey 3), and 2399 (survey 4) individuals were included in the analyses. In the 6 months-4 years age group, the lowest prevalence (assessed using microscopy) was observed in 2 Tanzan...Continue Reading

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Citations

Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Omari A MsemoJohn P A Lusingu
Jul 7, 2019·Scientific Reports·Tamirat Gebru WoldearegaiJana Held
Jun 4, 2020·Malaria Journal·Paddington T Mundagowa, Pugie T Chimberengwa
Jun 14, 2020·BMC Public Health·Griffin J BellIrving Hoffman
Sep 23, 2020·The American Journal of Tropical Medicine and Hygiene· RTS,S Epidemiology EPI-MAL-005 Study Group The RTS,S Epidemiology EPI-MAL-005 Study Group Is Composed Of Per Alphabetical OrStéphanie Wéry

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Clinical Trials Mentioned

NCT01190202

Software Mentioned

Nanoro

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