PMID: 11314892Apr 21, 2001Paper

Longitudinal evaluation of GCF MMP-3 and TIMP-1 levels as prognostic factors for progression of periodontitis

Journal of Clinical Periodontology
T AlpagotR Rudin

Abstract

To determine whether matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in gingival crevicular fluid (GCF) could serve as prognostic factors for the progression of periodontitis, we monitored GCF MMP-3 and TIMP-1 and periodontal status of selected sites in 40 medically healthy subjects over a 6-month period. Clinical measurements including gingival index (GI), plaque index, bleeding on probing, suppuration, probing depth (PD), attachment loss (AL), and GCF samples were taken from 2 healthy sites (including sites with gingival recession, GI=0 PD < or =3 mm; AL < or =2 mm) and 2 periodontitis sites (GI > or =1; PD > or =5 mm; AL > or =3 mm) of each patient at baseline, 3-month and 6-month visits by means of sterile paper strips. GCF levels of MMP-3 and TIMP-1 were determined by sandwich ELISA assays. The mean amounts of MMP-3 and TIMP-1 in diseased sites were significantly higher than in healthy sites (p<0.0001). Significantly higher GCF levels of MMP-3 and TIMP-1 were found at progressing sites than in nonprogressing periodontitis sites (0.001<p<0.01). A progressing site was defined as a site which had > or =2 mm loss of attachment during 6- month study period. GCF levels of MMP-3 were highl...Continue Reading

References

Oct 15, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·K ObataT Hayakawa
Sep 1, 1992·Journal of Periodontal Research·Q T SmithJ L Stoltenberg
Jun 5, 1991·Journal of the National Cancer Institute·A AlbiniW G Stetler-Stevenson
Oct 1, 1989·Community Dentistry and Oral Epidemiology·J Bergström
Apr 1, 1981·The Biochemical Journal·T E CawstonJ J Reynolds
May 1, 1994·Journal of Periodontology·J Bergström, H Preber
Dec 1, 1993·Journal of Periodontology·J L StoltenbergG E Fischer
Feb 1, 1994·Journal of Periodontology·G C ArmitageT J Sharp
Mar 1, 1994·Journal of Periodontology·S G GrossiR J Genco
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler
Oct 1, 1995·Community Dentistry and Oral Epidemiology·J D BeckS Offenbacher
Nov 1, 1996·Journal of Clinical Periodontology·T AlpagotS D Tran
Feb 1, 1997·Journal of Clinical Periodontology·E E MachteiR J Genco
Dec 10, 1999·Journal of Clinical Periodontology·S SaidD F Kinane
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS
May 1, 1994·Journal of Periodontology·Jan Bergström, Hans Preber
May 1, 1994·Journal of Periodontology·Jan Bergström, Hans Preber

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Citations

Feb 23, 2010·Tobacco Induced Diseases·Miki Ojima, Takashi Hanioka
May 7, 2002·Journal of Periodontology·Richard J Oringer, UNKNOWN Research, Science, and Therapy Committee of the American Academy of Periodontology
Apr 8, 2004·Journal of Periodontology·Kosunique JenkinsRuth Carter Borghaei
Aug 17, 2005·Journal of Periodontology·Brian Burt, UNKNOWN Research, Science and Therapy Committee of the American Academy of Periodontology
May 5, 2006·Journal of Periodontology·Akihiko SakaiKoichi Ito
Apr 12, 2008·Journal of Oral Science·Balwant RaiSuresh C Anand
Jul 16, 2014·Journal of Indian Society of Periodontology·Nagireddy Ravindra ReddyAvula Kishore Kumar
Aug 1, 2014·Journal of Periodontology·Thiago MorelliSteven Offenbacher
Feb 17, 2015·Clinical Oral Implants Research·Christoph A RamseierGiovanni E Salvi
Dec 1, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D A TiptonM Kh Dabbous
Jun 26, 2007·Archives of Oral Biology·Tamer AlpagotNejat Duzguneş
Sep 2, 2005·Periodontology 2000·G Rutger Persson
Sep 1, 2005·Journal of Clinical Periodontology·Giovanni E Salvi, Niklaus P Lang
Feb 6, 2004·Journal of Clinical Periodontology·T AlpagotA Lee
Jan 14, 2004·Periodontology 2000·Gary C Armitage
Aug 25, 2007·Journal of Clinical Periodontology·Marcela HernándezJorge Gamonal
Feb 26, 2011·Journal of Clinical Periodontology·Nurcan Buduneli, Denis F Kinane
Oct 31, 2012·Journal of Periodontal Research·D A TiptonM Kh Dabbous
Oct 13, 2012·Journal of Periodontal Research·R SchureC A McCulloch
Mar 18, 2010·Oral Diseases·A OyarzúnP C Smith
Apr 30, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nurdan Ozmeric
Mar 27, 2003·Periodontology 2000·Catherine M E ChampagneSteven Offenbacher

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