PMID: 7541528Jul 1, 1995Paper

Longitudinal evaluation of serum androgen levels in men with and without prostate cancer

The Prostate
H Ballentine CarterP C Walsh

Abstract

Androgens are thought to play a role in the pathogenesis of prostate cancer. We evaluated androgen levels in 3 age-matched groups of men who were part of the Baltimore Longitudinal Study of Aging: 1) 16 men with no prostatic disease by urologic history and exam (control group); 2) 20 men with a histologic diagnosis of benign prostatic hyperplasia (BPH) who had undergone simple prostatectomy; and 3) 20 men with a histologic diagnosis of prostate cancer (16 with local/regional cancer, and 4 with metastatic cancer). Luteinizing hormone (LH), total testosterone (T), and free T were measured on stored AM sera by radioimmunoassay (RIA). Free T was also calculated from the measured concentrations of total T and sex hormone binding globulin (SHBG). The median number of repeated sex steroid measurements ranged from 6-9 over a period from 7-25 years prior to the diagnosis of prostate disease. There were no significant differences in age-adjusted LH, total T, SHBG, or calculated free T levels among the groups at 0-5, 5-10, and 10-15 years before diagnosis. These data suggest that there are no measurable differences in serum testosterone levels among men who are destined to develop prostate cancer and those without the disease.

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Citations

Jul 12, 2002·The Prostate·Ann W HsingFrank Z Stanczyk
Oct 22, 2005·Current Urology Reports·Stephen Lazarou, Abraham Morgentaler
Feb 25, 2003·Urology·Sameer N StasRidwan Shabsigh
Oct 11, 2003·Urology·James A EasthamUNKNOWN Polyp Prevention Trial Study Group
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