Longitudinal evaluation of visual P300 amplitude in clinical high-risk subjects: An event-related potential study.

Psychiatry and Clinical Neurosciences
Naoya OribeMargaret A Niznikiewicz

Abstract

We previously reported abnormal P300 and N200 in a visual oddball task, and progressive P300 amplitude reduction at 1-year follow-up in patients with first-episode schizophrenia. P300 reduction as well as intact P1/N1 were also observed in clinical high-risk subjects (CHR), but whether or not these components change over time is unknown. This study evaluates, longitudinally, the visual P300, as well as P1, N1, and N200, in CHR. Visual event-related potentials (ERP) were recorded twice, once at baseline and once at 1-year follow-up in CHR (n = 19) and healthy comparison subjects (HC; n = 28). Participants silently counted infrequent target stimuli ('x') among standard stimuli ('y') presented on the screen while the 64-channel electroencephalogram was recorded. No CHR converted to psychosis from baseline to 1-year follow-up in this study. Visual P300 amplitude was reduced and the latency was delayed significantly in CHR at both time points compared with HC. Furthermore, CHR subjects who had more positive symptoms showed more amplitude reduction at both time points. P1, N1, and N200 did not differ between groups. Visual P300 amplitude was found to be reduced in CHR individuals compared with HC. We note that this finding is in subj...Continue Reading

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Citations

Oct 27, 2020·Frontiers in Psychiatry·Naotoshi OharaToshiaki Onitsuka
Mar 7, 2021·Journal of Personalized Medicine·Jinya SatoToshiaki Onitsuka
Feb 20, 2021·Frontiers in Psychiatry·Yoji Hirano, Peter J Uhlhaas
Mar 17, 2021·Neuropsychologia·Giulia EllenaElisabetta Làdavas
May 22, 2021·Frontiers in Psychiatry·Andrea PerrottelliArmida Mucci
Aug 20, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Shinsuke KoikeYoji Hirano
Oct 31, 2021·Psychiatry and Clinical Neurosciences·Toshiaki OnitsukaRyota Hashimoto

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