Longitudinal Flow Cytometry Identified "Minimal Residual Disease" (MRD) Evolution Patterns for Predicting the Prognosis of Patients with Transplant-Eligible Multiple Myeloma

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Jingli GuJ Li

Abstract

Many questions about minimal residual disease (MRD) still need to be answered for multiple myeloma (MM). Flow MRD was monitored in 104 consecutive patients with MM after induction and at the 3rd, 6th, 9th, 12th, 18th, and 24th months post-transplant. Four MRD evolution patterns were revealed: Pattern 1 patients had persistent MRD-negative status after post-induction with no progression; pattern 2 patients had MRD-positive status postinduction but became MRD negative within 24 months post-transplant; pattern 3 patients had MRD-negative status postinduction but became MRD positive within 24 months post-transplant; and pattern 4 patients had persistent MRD-positive status after postinduction. Patients with MRD evolution pattern 1 had a better time to progression than did patients with the other evolution patterns (not reached versus not reached, versus 15.4 ± 2.4 months, versus 16.9 ± 3.0 months; log-rank test, P = .003, P = .000, and P = .000, respectively). Patients with MRD pattern 1 had a significantly longer overall survival than did patients with pattern 3 (not reached versus 35.2 ± 18.6 months; log-rank test, P = .000) and pattern 4 (not reached versus 23.8 ± 15.0 months, log-rank test, P = .000) but had a similar overall s...Continue Reading

Citations

Feb 23, 2020·Frontiers in Oncology·Stefania OlivaAlessandra Larocca
Dec 7, 2019·Hematology·Elisabet E Manasanch
Sep 22, 2020·Panminerva Medica·Chandramouli NagarajanClaudio Cerchione
Jan 30, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hervé Avet-LoiseauNizar J Bahlis
May 10, 2021·Journal of Cancer Research and Clinical Oncology·Xiaozhe LiJuan Li
Jun 3, 2021·International Journal of Molecular Sciences·Vanessa InnaoSebastiano Gangemi
Oct 16, 2021·Biomarker Research·Hong DingYuhuan Zheng

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