Longitudinal follow-up of fibrosing interstitial pneumonia: relationship between physiologic testing, computed tomography changes, and survival rate

Journal of Thoracic Imaging
Jeong-Hwa HwangDavid A Lynch

Abstract

The aim of this study was to evaluate the prognostic implications of computed tomography (CT) and physiologic variables at baseline and on sequential evaluation in patients with fibrosing interstitial pneumonia. We identified 72 patients with fibrosing interstitial pneumonia (42 with idiopathic disease, 30 with collagen vascular disease). Pulmonary function tests and CT were performed at the time of diagnosis and at a median follow-up of 12 months, respectively. Two chest radiologists scored the extent of specific abnormalities and overall disease on baseline and follow-up CT. Rate of survival was estimated using the Kaplan-Meier method. Three Cox proportional hazards models were constructed to evaluate the relationship between CT and physiologic variables and rate of survival: model 1 included only baseline variables, model 2 included only serial change variables, and model 3 included both baseline and serial change variables. On follow-up CT, the extent of mixed ground-glass and reticular opacities (P<0.001), pure reticular opacity (P=0.04), honeycombing (P=0.02), and overall extent of disease (P<0.001) was increased in the idiopathic group, whereas these variables remained unchanged in the collagen vascular disease group. Pa...Continue Reading

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Citations

Feb 24, 2016·AJR. American Journal of Roentgenology·James F Gruden
Apr 5, 2016·Journal of Thoracic Imaging·Maria D MartinJeffrey P Kanne
Feb 26, 2019·Journal of Thoracic Imaging·Joseph G MammarappallilBastiaan Driehuys
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May 16, 2019·The British Journal of Radiology·Michael P MohningTristan J Huie
Jul 6, 2021·Current Opinion in Pulmonary Medicine·Anand DevarajNicola Sverzellati

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