Longitudinal follow-up study: effect of psychological co-morbidity on the prognosis of inflammatory bowel disease.

Alimentary Pharmacology & Therapeutics
Keeley M FairbrassAlexander C Ford

Abstract

Psychological co-morbidity is more common in patients with inflammatory bowel disease (IBD), compared with the general population, but little is known about the cumulative effect of increasing psychological burden on disease behaviour. To examine the effect of psychological co-morbidity on inflammatory bowel disease in a longitudinal follow-up study. We collected complete demographic, symptom and psychological co-morbidity data (anxiety, depression and somatisation scores) at baseline from adults with IBD in biochemical remission (faecal calprotectin <250 µg/g). Objective markers of disease activity, including glucocorticosteroid prescription or flare of disease activity, escalation of therapy, hospitalisation or intestinal resection, were reviewed ≥2 years of follow-up. We performed multivariate Cox regression, controlling for patient characteristics and follow-up duration, to examine cumulative effect of psychological co-morbidities on subsequent IBD behaviour. Among 218 participants, 48 (22.0%) had one, 13 (6.0%) two and nine (4.1%) three psychological co-morbidities at baseline. Following multivariate Cox regression analysis, glucocorticosteroid prescription or flare, and escalation of medical therapy were significantly hig...Continue Reading

References

Mar 8, 1980·Lancet·R F Harvey, J M Bradshaw
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Oct 15, 1998·Gut·R S WalmsleyR N Allan
Apr 8, 2003·Scandinavian Journal of Gastroenterology·S L JowettM R Welfare
Jan 26, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Severine VermeirePaul Rutgeerts
Jan 8, 2013·Alimentary Pharmacology & Therapeutics·A N AnanthakrishnanK P Liao
Apr 8, 2014·European Archives of Psychiatry and Clinical Neuroscience·Guillaume FondLaurent Boyer
Jan 29, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Antonina Mikocka-WalusUNKNOWN Swiss IBD Cohort Study Group
May 18, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David J GracieAlexander C Ford
Jul 15, 2016·Journal of Psychosomatic Research·Rachel NeuendorfHelané Wahbeh
Mar 8, 2017·Inflammatory Bowel Diseases·Benjamin J D MacerAntonina Mikocka-Walus
Mar 9, 2017·Acta Neuropsychiatrica·Áine Abautret-DalyAndrew Harkin
Nov 4, 2017·Epidemiology and Psychiatric Sciences·R A MarrieUNKNOWN CIHR Team in Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease
Jan 26, 2018·Gastroenterology·David J GracieAlexander C Ford
Feb 1, 2018·Therapeutic Advances in Gastroenterology·Yannick DerwaDavid J Gracie
May 28, 2019·The Lancet. Gastroenterology & Hepatology·David J GracieAlexander C Ford
Aug 17, 2019·Alimentary Pharmacology & Therapeutics·Tamara MogilevskiPeter R Gibson
Nov 13, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L A SceatsC Kin
Jul 24, 2020·The Lancet. Gastroenterology & Hepatology·Priya OkaAlexander C Ford
Mar 16, 2021·The Lancet. Gastroenterology & Hepatology·Brigida BarberioAlexander C Ford
May 14, 2021·The American Journal of Gastroenterology·Irina MidenfjordMagnus Simrén

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