Longitudinal genetic analysis of brain volumes in normal elderly male twins.

Neurobiology of Aging
Christina N Lessov-SchlaggarDorit Carmelli

Abstract

This study investigated the role of genetic and environmental influences on individual differences in brain volumes measured at 2 time points in normal elderly males from the National Heart, Lung, and Blood Institute Twin Study. The magnetic resonance imaging (MRI) scans were conducted 4 years apart on 33 monozygotic and 33 dizygotic male twin pairs, aged 68 to 77 years when first scanned. Volumetric measures of total brain and total cerebrospinal fluid were significantly heritable at baseline (over 70%). For both volumes genetic influences at follow-up were entirely accounted for by genetic influences at baseline, suggesting that the same genetic factors influence variability in brain volume at each time of assessment. Variability in 4-year volume change was due to shared and individual-specific environmental influences. There was little evidence for heritable influences on change measures. These results suggest that variation in longitudinal change of some brain volume measures may have different underlying genetic and environmental architecture from variation in repeat cross-sectional measures, which could have implications for intervention strategies for age-related illness associated with brain morphology. The results of t...Continue Reading

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Citations

Oct 23, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Ruth E KrasnowGary E Swan
Aug 8, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Thomas J Bouchard
Mar 8, 2014·Behavior Genetics·Thomas J Bouchard
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Oct 28, 2015·NeuroImage·Kristine B WalhovdAnders M Fjell
Apr 21, 2017·PloS One·Matthew W LukiesUNKNOWN Osaka University Twin Research Group
Dec 21, 2017·Communicative & Integrative Biology·Jaroslav Flegr
Jun 4, 2020·Cerebral Cortex·Andjela MarkovicLeila Tarokh
Oct 10, 2015·Stroke; a Journal of Cerebral Circulation·Edith HoferUNKNOWN Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Apr 24, 2020·Neuroscience and Biobehavioral Reviews·Paula Iso-MarkkuIna M Tarkka

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