Longitudinal In Vivo Characterization of the Streptozotocin-Induced Diabetic Mouse Model: Focus on Early Inner Retinal Responses

Investigative Ophthalmology & Visual Science
Jurgen SergeysTine Van Bergen

Abstract

The goal of this study was to perform an extensive temporal characterization of the early pathologic processes in the streptozotocin (STZ)-induced diabetic retinopathy (DR) mouse model, beyond the vascular phenotype, and to investigate the potential of clinically relevant compounds in attenuating these processes. Visual acuity and contrast sensitivity (CS) were studied in the mouse STZ model until 24 weeks postdiabetes onset. ERG, spectral domain optical coherence tomography (SD-OCT), leukostasis, and immunohistochemistry were applied to investigate neurodegeneration, inflammation, and gliosis during early-, mid- and late-phase diabetes. Aflibercept or triamcinolone acetonide (TAAC) was administered to investigate their efficacy on the aforementioned processes. Visual acuity and CS loss started at 4 and 18 weeks postdiabetes onset, respectively, and progressively declined over time. ERG amplitudes were diminished and OP latencies increased after 6 weeks, whereas SD-OCT revealed retinal thinning from 4 weeks postdiabetes. Immunohistochemical analyses linked these findings to retinal ganglion and cholinergic amacrine cell loss at 4 and 8 weeks postdiabetes onset, respectively, which was further decreased after aflibercept adminis...Continue Reading

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Citations

Aug 26, 2020·Investigative Ophthalmology & Visual Science·Elena IvanovaBotir T Sagdullaev
Sep 17, 2020·Visual Neuroscience·Erika D Eggers, Teresia A Carreon
Jan 22, 2020·Neural Regeneration Research·Elisabetta Catalani, Davide Cervia
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Jun 28, 2019·Journal of Clinical Medicine·Todd McLaughlinSarah X Zhang
Jan 8, 2021·Acta Neuropathologica Communications·Marjan VandenabeeleLies De Groef
Mar 25, 2021·Current Eye Research·Tuna Celik BuyuktepeEmin Özmert
Apr 4, 2021·International Journal of Molecular Sciences·Jorge González-CasanovaDiana Rojas-Gomez
Jun 3, 2021·International Journal of Molecular Sciences·Marie ClaesLieve Moons
Jul 8, 2021·Investigative Ophthalmology & Visual Science·Rosario AmatoVittorio Porciatti
Aug 20, 2021·Investigative Ophthalmology & Visual Science·Sarah R SheskeyCheng-Mao Lin
Dec 30, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anna R ConnellJeremy Y Yu

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