Longitudinal increases in blood biomarkers of inflammation or cardiovascular disease and the incidence of venous thromboembolism

Journal of Thrombosis and Haemostasis : JTH
Aaron R FolsomChristie M Ballantyne

Abstract

Essentials Inflammatory and cardiac diseases are associated with increased venous thromboembolism (VTE) risk. Our prospective study assessed rise in inflammatory or cardiac biomarkers and VTE risk. A greater 6-year rise in N-terminal natriuretic peptide is associated with increased VTE incidence. Volume overload or impending cardiac disease may contribute to VTE occurrence. Background We previously showed that participants in the population-based Atherosclerosis Risk in Communities (ARIC) cohort with elevated levels of blood biomarkers of inflammation or cardiac disease were at increased risk of venous thromboembolism (VTE). Objective We hypothesized that ARIC participants with larger 6-year increases in the levels of three biomarkers - C-reactive protein (CRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and troponin T - would also have an increased subsequent risk of VTE. Methods We measured changes in the levels of these biomarkers in 9844 participants from 1990-1992 to 1996-1998, and then identified VTEs through 2015. Results A greater 6-year rise in the level of NT-proBNP, but not in that of CRP or troponin T, was significantly associated with increased VTE incidence over a median of 17.6 years of follow-up. Aft...Continue Reading

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Citations

Feb 26, 2019·Journal of Thrombosis and Haemostasis : JTH·Antonio P Arenas de LarrivaAaron R Folsom
Mar 28, 2021·Journal of Thrombosis and Haemostasis : JTH·Line H EvensenPamela L Lutsey
Oct 7, 2021·Diabetes/metabolism Research and Reviews·João Leonardo Silveira RossiLance Alan Sloan

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