Longitudinal investigation of the role of cognitive reserve in the evolution of dementia in outpatients prescribed AChEI.

Journal of Clinical and Experimental Neuropsychology
Maria DevitaAlessandra Coin

Abstract

Aim: The role of cognitive reserve (CR) in modulating dementia has been broadly investigated. We aimed to evaluate the long-term effects of CR on cognitive functions in outpatients newly treated with acetylcholinesterase inhibitors.Method: Fifty older adults with dementia (age 80 ± 6.4 years) were followed up over 27 months. CR was assessed with the Cognitive Reserve Index questionnaire (CRIq), which provides a Total CR index and three proxy measures: Education, Working Activity and Leisure Time. The association between CR and cognition, evaluated by the Mini-Mental State Examination (MMSE), was tested through linear mixed models.Results: The cognitive profile of High CR individuals (n = 16) was more fluctuating than that of patients with Low CR (n = 34) up to 15 months of treatment, showingan alternation of improvements and worsening. At linear mixed models, CRIq Total score was significantly associated with MMSE over the follow-up either when considered as continuous (β = 0.13 [95%CI:0.07-0.19], p < .001, per each 1-unit increase) orcategorical variable (β = 3.62 [95%CI:1.77-5.47], p = .002, High vs Low CR). Among the CR domains, higher CRIq Leisure-time scores were significantly associated with higher MMSE during the follow-...Continue Reading

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Citations

Feb 2, 2021·Neuropsychologia·Fabio CampanellaMiran Skrap

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Software Mentioned

R
piecewiseSEM
R lme4
SPSS
emmeans

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