Longitudinal medication usage in Alzheimer disease patients.

Alzheimer Disease and Associated Disorders
Carolyn W ZhuY Stern

Abstract

This study examined in detail patterns of cholinesterase inhibitors (ChEIs) and memantine use and explored the relationship between patient characteristics and such use. Patients with probable Alzheimer disease AD (n=201) were recruited from the Predictors Study in 3 academic AD centers and followed from early disease stages for up to 6 years. Random effects logistic regressions were used to examine effects of patient characteristics on ChEIs/memantine use over time. Independent variables included measures of function, cognition, comorbidities, the presence of extrapyramidal signs, psychotic symptoms, age, sex, and patient's living situation at each interval. Control variables included assessment interval, year of study entry, and site. During a 6-year study period, rate of ChEIs use decreased (80.6% to 73.0%) whereas memantine use increased (2.0% to 45.9%). Random effects logistic regression analyses showed that ChEI use was associated with better function, no psychotic symptoms, and younger age. Memantine use was associated with better function, poorer cognition, living at home, later assessment interval, and later year of study entry. Results suggest that high rate of ChEI use and increasing memantine use over time are consi...Continue Reading

References

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Citations

Dec 3, 2014·Neurología : publicación oficial de la Sociedad Española de Neurología·M C de Hoyos-AlonsoA Otero
Feb 4, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michelle M MielkeConstantine G Lyketsos
Nov 8, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sophie Gillette-GuyonnetUNKNOWN REAL.FR study group
Jun 15, 2011·Journal of the American Geriatrics Society·Carole ParsonsJennifer Tjia
Jan 22, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Carolyn W ZhuYaakov Stern
May 25, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yaakov SternOksana Tatarina
Dec 18, 2019·Psychiatry and Clinical Neurosciences·Natalie SeilerBrian O'Donoghue
Feb 24, 2015·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Colleen J MaxwellNathan Herrmann

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