PMID: 9533259Apr 9, 1998Paper

Longitudinal models for AIDS marker data

Statistical Methods in Medical Research
W J BoscardinN Law

Abstract

Over the past decade, researchers have put a great amount of effort into developing suitable models for the analysis of longitudinal CD4 data and other markers of AIDS progression. These models must be general enough to allow for different patterns of change in the marker data. In this paper, we review the existing literature including our preferred models which involve mixed effects, stochastic terms and independent measurement error. Adding stochastic terms to standard mixed effects models gives an interpretable and parsimonious method for generalizing the covariance structure of the measurement error and short-term variability. We focus on univariate and bivariate models with integrated Ornstein-Uhlenbeck (IOU) stochastic terms. The IOU process allows for a range of biologically plausible derivative tracking that encompasses both random trajectory and Brownian motion behaviour. We illustrate these modelling techniques on longitudinal CD4 and viral RNA data.

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Citations

May 8, 2001·Statistical Methods in Medical Research·C A Donnelly
May 8, 2001·Statistical Methods in Medical Research·G M Raab, T Parpia
May 8, 2001·Statistical Methods in Medical Research·N G Becker, I C Marschner
Apr 30, 2008·Statistics in Medicine·Patrick TafféUNKNOWN Swiss HIV Cohort Study
Apr 27, 2012·Statistical Methods in Medical Research·Ronald B Geskus
Mar 15, 2012·Statistics in Medicine·S E HolteJ Overbaugh
Oct 21, 2016·Medicine·Rafael SauterUNKNOWN and the Swiss HIV cohort study
Oct 28, 2019·Model Assisted Statistics and Applications : an International Journal·Vinay K Cheruvu, Jeffrey M Albert
Jun 4, 2002·Statistical Methods in Medical Research·D Commenges
Nov 27, 2016·Journal of Gastroenterology and Hepatology·Jia LiUNKNOWN CHeCS Investigators
Feb 16, 2007·AIDS·Pierre-Yves BochudUNKNOWN Swiss HIV Cohort Study
Aug 11, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Farzad Noubary, Michael D Hughes
Aug 28, 2021·Statistical Methods in Medical Research·Tianmeng LyuYifei Sun

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