PMID: 9174216Apr 1, 1997Paper

Longitudinal monitoring of bone mineral density in thalassemic patients. Genetic structure and osteoporosis

Acta Paediatrica
A FilosaL Pagano

Abstract

The changes in bone mineral density (BMD) measured by single photon absorptiometry (SPA) using two observations conducted over a period of 2 years were examined in 54 thalassemic subjects [30 F(A) and 24 M(B)] with a chronological age ranging from 2.6 to 22.6 years and in 27 sex- and age-matched controls (C). Each category (A, B and C) was divided into three groups according to pubertal signs: pre-pubertal subjects (A1, B1 and C1); peri-pubertal subjects (A2, B2 and C2) and pubertal subjects from the first observation (A3, B3 and C3). Furthermore, each group of patients was divided into sub-groups on the basis of haematological phenotypes, those with a more severe form were called beta0/beta0 while those with other forms were called "others". The most significant findings were the following: the presence of a more severe reduction of the bone mineral density in patients with the beta0/beta0 phenotype than in patients with the "others" phenotype; patients with hypogonadism corresponded to the beta0/beta0 phenotype, while those with spontaneous puberty corresponded to the "others" phenotype. In conclusion, since puberty and the degree of bone mineral density are related to the haematological phenotype, puberty (spontaneous or ind...Continue Reading

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Citations

Feb 28, 2006·Journal of Bone and Mineral Metabolism·Nicholas G AngelopoulosGeorge Tolis
Dec 21, 2000·British Journal of Haematology·R Dresner PollackA W Goldfarb
Jan 25, 2003·British Journal of Haematology·Basia K BielinskiNick J Shaw
Nov 11, 2003·Journal of Pediatric Hematology/oncology·Jimmy P S ChernSu Heuy Lo
Apr 1, 1999·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Z C Orlic, L G Raisz
Oct 27, 2010·Journal of Osteoporosis·Meropi Toumba, Nicos Skordis
Jul 8, 1999·The New England Journal of Medicine·N F Olivieri
Sep 13, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Somnuek DomrongkitchaipornRajata Rajatanavin
Apr 26, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Phillip WongFrances Milat
Jul 11, 2012·International Journal of Endocrinology·Ibrahim AslanRuya Cosan
Jun 19, 2013·Carbohydrate Polymers·Zhihong TongBo He
Nov 6, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria G VogiatziPatricia J Giardina
Sep 30, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sakineh MohammadianAb Sadeghi-Nejad
Jun 28, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Fadhli Mohamed SaniMehmet Bilgen
Jun 11, 2016·Biomedical Reports·Ahmed Al-AkhrasMarwa Zakaria
Jul 14, 2019·Endocrine·Fabio PellegrinoMaria Rosaria Ambrosio

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