Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus

Lupus
A M KatramadosP D Mitsias

Abstract

A healthy boy developed subacutely progressive quadriparesis, complicated by sudden paraplegia, fever, and meningeal signs, diagnosed as longitudinal myelitis, aseptic meningitis, and conus medullaris infarction and identified as the presenting manifestations of neuropsychiatric systemic lupus erythematosus. Rapid expansion of the conus on serial neuroimaging led to emergent decompressive laminectomy and cord biopsy showing vasculitis and cord infarction. The patient had partial recovery after treatment with high-dose steroids. Increased vigilance is required when pediatric patients develop a similar subacute presentation on the ground of active systemic lupus erythematosus because it may herald the onset of a catastrophic neurological syndrome.

References

Sep 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·J Provenzale, T W Bouldin
Jul 1, 1968·Medicine·R T Johnson, E P Richardson
Aug 10, 2000·Acta neurochirurgica·R Greiner-PerthR Both
Feb 6, 2004·JAMA : the Journal of the American Medical Association·Steven R LevineUNKNOWN APASS Investigators
Jul 28, 2004·Clinical Rheumatology·Mohamed O OlfatMohamed A Muzaffer
Aug 16, 2006·Archives of Neurology·Jan NovyJulien Bogousslavsky
Dec 30, 2006·Arthritis and Rheumatism·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics

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Citations

Nov 29, 2012·Neurologic Clinics·Shin C BehElliot M Frohman
Nov 29, 2011·World Neurosurgery·Michael FuKetan R Bulsara
Nov 16, 2014·Neuroradiology·Stefan WeidauerJoachim Berkefeld
Jan 30, 2019·Journal of Neurology·M J WendebourgR Schlaeger
Dec 17, 2008·Current Opinion in Rheumatology

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