Longitudinal Network Changes and Conversion to Cognitive Impairment in Multiple Sclerosis.

Neurology
Marijn HuiskampMenno M Schoonheim

Abstract

To characterize functional network changes related to conversion to cognitive impairment in a large sample of patients with multiple sclerosis (MS) over a period of 5 years. Two hundred twenty-seven patients with MS and 59 healthy controls of the Amsterdam MS cohort underwent neuropsychological testing and resting-state fMRI at 2 time points (time interval 4.9 ± 0.9 years). At both baseline and follow-up, patients were categorized as cognitively preserved (CP; n = 123), mildly impaired (MCI; z < -1.5 on ≥2 cognitive tests, n = 32), or impaired (CI; z < -2 on ≥2 tests, n = 72), and longitudinal conversion between groups was determined. Network function was quantified with eigenvector centrality, a measure of regional network importance, which was computed for individual resting-state networks at both time points. Over time, 18.9% of patients converted to a worse phenotype; 22 of 123 patients who were CP (17.9%) converted from CP to MCI, 10 of 123 from CP to CI (8.1%), and 12 of 32 patients with MCI converted to CI (37.5%). At baseline, default-mode network (DMN) centrality was higher in CI individuals compared to controls (p = 0.05). Longitudinally, ventral attention network (VAN) importance increased in CP, driven by stable CP ...Continue Reading

References

May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·A AchironY Harel
Sep 20, 2006·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictBianca Weinstock-Guttman
May 10, 2008·Neuron·Maurizio CorbettaGordon L Shulman
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jun 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Declan T ChardClaudia A M Wheeler-Kingshott
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·David J HawellekAndreas K Engel
Apr 20, 2013·Trends in Cognitive Sciences·Jordan PoppenkLynn Nadel
Apr 2, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Matteo PardiniLuca Roccatagliata
Mar 17, 2015·NeuroImage·Raimon H R PruimChristian F Beckmann
Oct 2, 2015·Nature Communications·Shi GuDanielle S Bassett
Feb 26, 2016·Brain : a Journal of Neurology·Lukas HaiderHans Lassmann
May 28, 2016·Cerebral Cortex·Lingzhong FanTianzi Jiang
Mar 27, 2018·Lancet·Alan J ThompsonOlga Ciccarelli
Sep 29, 2018·Lancet Neurology·Maria A RoccaUNKNOWN MAGNIMS Study Group
Oct 12, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Rosalind KalbJohn DeLuca
Apr 4, 2019·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Muhua HuangHonghan Gong
Sep 6, 2019·Neurology·Anand J C EijlersJeroen J G Geurts
Sep 11, 2019·Brain : a Journal of Neurology·Ismail KoubiyrAurélie Ruet
Sep 20, 2020·Lancet Neurology·Ralph H B BenedictJeroen J G Geurts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.