Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans.

Nature Microbiology
Jeffrey SeowKatie J Doores

Abstract

Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10-15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human population, it is not known how long antibody responses will be maintained or whether they will provide protection from reinfection. Using sequential serum samples collected up to 94 d post onset of symptoms (POS) from 65 individuals with real-time quantitative PCR-confirmed SARS-CoV-2 infection, we show seroconversion (immunoglobulin (Ig)M, IgA, IgG) in >95% of cases and neutralizing antibody responses when sampled beyond 8 d POS. We show that the kinetics of the neutralizing antibody response is typical of an acute viral infection, with declining neutralizing antibody titres observed after an initial peak, and that the magnitude of this peak is dependent on disease severity. Although some individuals with high peak infective dose (ID50 > 10,000) maintained neutralizing antibody titres >1,000 at >60 d POS, some with lower peak ID50 had neutralizing antibody titres approaching baseline within the follow-up period. A similar decline in neutralizing antibody titres was observed in a cohort of 31 seropositive healthcare workers. The present study...Continue Reading

References

Oct 1, 1990·Epidemiology and Infection·K A CallowD A Tyrrell
Aug 23, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Nelson LeeDavid S Hui
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hongying MoNanshan Zhong
Sep 15, 2007·The New England Journal of Medicine·Wu-Chun CaoJan H Richardus
Nov 9, 2007·The New England Journal of Medicine·Ian J AmannaMark K Slifka
Jun 7, 2017·Emerging Infectious Diseases·Pyoeng Gyun ChoeMyoung-Don Oh
Apr 9, 2020·Emerging Infectious Diseases·Nisreen M A OkbaBart L Haagmans
Apr 23, 2020·Nature Reviews. Immunology·Akiko Iwasaki, Yexin Yang
May 1, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
May 14, 2020·Nature Medicine·Fatima AmanatFlorian Krammer
May 21, 2020·The Journal of General Virology·Paul Kellam, Wendy Barclay
May 21, 2020·Nature Communications·Trevor R F SmithKate E Broderick
May 22, 2020·Science·Jingyou YuDan H Barouch
May 22, 2020·Science·Abishek ChandrashekarDan H Barouch
Jun 20, 2020·Nature·Davide F RobbianiMichel C Nussenzweig
Jun 20, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Jul 7, 2020·The Lancet Infectious Diseases·Eskild PetersenLone Simonsen
Jul 15, 2020·The New England Journal of Medicine·Lisa A JacksonUNKNOWN mRNA-1273 Study Group
Jul 22, 2020·The Journal of Experimental Medicine·Fabian SchmidtPaul D Bieniasz
Jul 30, 2020·The New England Journal of Medicine·Kizzmekia S CorbettBarney S Graham
Jul 31, 2020·Nature·Neeltje van DoremalenVincent J Munster
Aug 4, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kai WangAi-Long Huang
Aug 15, 2020·MedRxiv : the Preprint Server for Health Sciences·Frauke MueckschPaul D Bieniasz
Aug 19, 2020·Nature Medicine·Adam G LaingAdrian C Hayday
Aug 21, 2020·MedRxiv : the Preprint Server for Health Sciences·Lauren B RoddaMarion Pepper
Sep 3, 2020·The New England Journal of Medicine·Cheryl KeechGregory M Glenn
Sep 13, 2020·Journal of Clinical Microbiology·Larry L LuchsingerTheodora Hatziioannou
Sep 16, 2020·Nature Medicine·Arthur W D EdridgeLia van der Hoek
Oct 2, 2020·The Journal of Infectious Diseases·Katharine H D CrawfordJesse D Bloom
Oct 6, 2020·Cell Reports Medicine·Jérémie PrévostAndrés Finzi
Oct 18, 2020·MBio·Guillaume Beaudoin-BussièresAndrés Finzi
Feb 4, 2021·The Journal of Infectious Diseases·Katharine H D CrawfordJesse D Bloom
Jul 11, 2020·MedRxiv : the Preprint Server for Health Sciences·William T LeeK. A. McDonough

❮ Previous
Next ❯

Citations

Nov 11, 2020·Biochemical Society Transactions·Jiayue-Clara Jiang, Yan Zhang
Nov 28, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Claudia Santos-HövenerThomas Lampert
Dec 4, 2020·Human Vaccines & Immunotherapeutics·Vipin M Vashishtha, Puneet Kumar
Dec 9, 2020·Science Translational Medicine·Zijun WangMichel C Nussenzweig
Dec 16, 2020·ELife·Eric Poeschla
Nov 5, 2020·Environmental Microbiology·Harald Brüssow
Nov 20, 2020·Journal of Crohn's & Colitis·Roberto Berte'Flavio Caprioli
Nov 20, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jaclyn C LawMario A Ostrowski
Jan 1, 2021·PloS One·Nathan PostSharif A Ismail
Nov 21, 2020·The Journal of Clinical Investigation·David K Meyerholz, Stanley Perlman
Jan 5, 2021·Frontiers in Immunology·Yannick GalipeauMarc-André Langlois
Dec 29, 2020·Science Immunology·Catherine J ReynoldsRosemary J Boyton
Jan 12, 2021·Advanced Drug Delivery Reviews·Jatin MachhiBhavesh D Kevadiya
Dec 19, 2020·Journal of the Pediatric Infectious Diseases Society·Emily ParsonsRebecca Sainato
Dec 21, 2020·The Lancet Infectious Diseases·Els DuysburghIsabelle Desombere
Jan 28, 2021·Vaccines·Ivana KnezevicHye-Na Kang
Jan 7, 2021·Trends in Immunology·Liriye Kurtovic, James G Beeson
Dec 29, 2020·Advanced Drug Delivery Reviews·Jee Young ChungYoung Jik Kwon
Feb 4, 2021·Risk Analysis : an Official Publication of the Society for Risk Analysis·David C Rode, Paul S Fischbeck
Feb 6, 2021·ACS Sensors·Guoqiang Liu, James F Rusling
Dec 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Anna Christine NilssonSøren Thue Lillevang
Jan 19, 2021·Nature·Christian GaeblerMichel C Nussenzweig
Feb 10, 2021·Immunological Reviews·Alice R Burton, Mala K Maini
Dec 15, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laith J Abu-RaddadRoberto Bertollini
Feb 14, 2021·International Immunopharmacology·Masoomeh MasoomikarimiReza Jafari
Nov 20, 2020·Vaccines·Hyunsuh KimRichard J Webby
Feb 2, 2021·Cell Reports Medicine·Thomas VoglEran Segal
Feb 5, 2021·International Journal of Environmental Research and Public Health·Antonella De DonnoPietro Alifano
Feb 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Julien FavresseJonathan Douxfils
Feb 11, 2021·Journal of Clinical Medicine·Tatjana WelzelJasmin B Kuemmerle-Deschner
Dec 11, 2020·Leukemia·J O'NionsL E McCoy
Dec 15, 2020·BMJ : British Medical Journal·Dipender Gill, Mark J Ponsford

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
ELISA
ELISAs

Software Mentioned

Moderna

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.