Longitudinal observation of children with enhanced total serum IgE

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Urszula DanilukDariusz Lebensztejn

Abstract

Long-term studies on the evolution of elevated total IgE (tIgE) concentration are in demand. To investigate the prevalence of allergic diseases and influential factors in children with high tIgE levels during a 5-year period. Children with high tIgE levels (>100 IU/mL) were study subjects. After the 5-year follow-up, an interview with the parents, clinical examination, and evaluation of tIgE and specific IgE (sIgE) to selected food and inhalant allergens were performed. The mean tIgE decreased significantly after 5 years in girls and boys regardless of the place of residence. Monosymptomatic patients accounted for most cases throughout the study, with the highest tIgE level at the beginning. After follow-up, the percentage of polysymptomatic patients increased. Their mean tIgE level was significantly higher than in the other groups. After follow-up, 11.7% of participants remained asymptomatic, and another 11.7% reported relief from symptoms. Allergy symptoms persisted in most children with normal tIgE levels. The 2-allergen sensitization was the most common through the study. Only patients sensitized to 4 allergens had unchanged levels of mean tIgE after follow-up and those with the highest mean tIgE level had a newly diagnosed...Continue Reading

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Citations

May 13, 2017·Allergy, Asthma & Immunology Research·Hye Jung ParkJoo Shil Lee
Mar 17, 2016·American Journal of Rhinology & Allergy·Jeong Hong KimJu Wan Kang
Jun 9, 2018·International Journal of Molecular Sciences·Jonatan LefflerDeborah H Strickland
Oct 10, 2020·Scandinavian Journal of Gastroenterology·Katarzyna ZdanowiczUrszula Daniluk
Dec 3, 2020·Journal of Clinical Medicine·Katarzyna ZdanowiczUrszula Daniluk

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