Longitudinal Pharmacokinetics of Mycophenolic Acid in Elderly Renal Transplant Recipients Compared to a Younger Control Group: Data from the nEverOld Trial

European Journal of Drug Metabolism and Pharmacokinetics
Paschoalina RomanoElias David-Neto

Abstract

Elderly patients are increasingly likely to be recipients of transplants. However, the pharmacokinetics of mycophenolic acid (MPA) in this population are yet to be studied in detail. The objective of this study was to assess whether there were differences in MPA pharmacokinetic parameter values between elderly recipients and younger-adult recipients during the 6 months immediately following renal transplantation. In this analysis, the longitudinal 12-h pharmacokinetics of MPA, administered as enteric-coated mycophenolate sodium (EC-MPS), were evaluated in 44 elderly renal transplant recipients and compared with the corresponding pharmacokinetics of MPA in 31 younger adult recipients. Measurements were performed at 7, 30, 60, 90, and 180 days post-transplantation. All patients received tacrolimus and prednisone. The elderly patients were 30 years older than the younger controls, with a predominance of males and Caucasians. Elderly patients had lower serum albumin than the younger controls during the first 6 months after transplantation. The mean estimated total body MPA clearance of the elderly recipients was not significantly different from that of the controls at any analyzed time point (the mean clearance across all time poin...Continue Reading

Associated Clinical Trials

References

Aug 1, 1979·Clinical Pharmacology and Therapeutics·E M SellersS M MacLeod
Mar 1, 1980·Digestive Diseases and Sciences·P V DesmondS Schenker
Apr 15, 1999·Age and Ageing·M ZoliG Marchesini
Sep 30, 1999·Drugs & Aging·J M Kovarik, E U Koelle
Oct 24, 2002·Gerontology·Abhinandana AnantharajuAntonio Chedid
May 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Leslie M ShawKenneth L Brayman
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gabriel M DanovitchRandall S Sung
Jul 26, 2005·Drugs & Aging·Christine E Staatz, Susan E Tett
Sep 6, 2005·Environmental Health Perspectives·Gary GinsbergBabasaheb Sonawane
Apr 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H-U Meier-KriescheA B Leichtman
Apr 22, 2006·Therapeutic Drug Monitoring·Teun van GelderRichard D Mamelok
May 16, 2006·Transplantation·Jaroslav RosenbergerJohan W Groothoff
Nov 16, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kyle N UtechtJill Kolesar
Oct 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y Le MeurP Marquet
Nov 21, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·C D HoltS V McDiarmid
Jan 9, 2009·Journal of the American Society of Nephrology : JASN·Dorry L SegevRobert A Montgomery
May 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R S GastonR D Bloom
Jun 2, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sieglinde KoflerIngo Kaczmarek
Jun 12, 2009·Drug Metabolism Reviews·Ulrich Klotz
Apr 13, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Roland HaubnerIrene J Virgolini
Oct 19, 2016·British Journal of Clinical Pharmacology·Jiang-Tao TangTeun van Gelder

❮ Previous
Next ❯

Citations

Dec 17, 2019·The Cochrane Database of Systematic Reviews·Deirdre HahnAngela C Webster
Apr 10, 2020·JCI Insight·Alexander J ValvezanBrendan D Manning

❮ Previous
Next ❯

Methods Mentioned

BETA
blood drawn

Clinical Trials Mentioned

NCT01631058

Software Mentioned

SPSS
MassLynx

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.