Oct 11, 2014

Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Michael C DonohueRobert A Rissman


Little is known about the utility of plasma amyloid beta (Aβ) in clinical trials of Alzheimer's disease (AD). We analyzed longitudinal plasma samples from two large multicenter clinical trials: (1) donezepil and vitamin E in mild cognitive impairment (n = 405, 24 months) and (2) simvastatin in mild to moderate AD (n = 225, 18 months). Baseline plasma Aβ was not related to cognitive or clinical progression. We observed a decrease in plasma Aβ40 and 42 among apolipoprotein E epsilon 4 (APOE ε4) carriers relative to noncarriers in the mild cognitive impairment trial. Patients treated with simvastatin showed a significant increase in Aβ compared with placebo. We found significant storage time effects and considerable plate-to-plate variation. We found no support for the utility of plasma Aβ as a prognostic factor or correlate of cognitive change. Analysis of stored specimens requires careful standardization and experimental design, but plasma Aβ may prove useful in pharmacodynamic studies of antiamyloid drugs.

  • References38
  • Citations4


Mentioned in this Paper

Mini-mental State Examination
Familial Alzheimer Disease (FAD)
Biological Regulation
APP protein, human
Apolipoprotein E4
Amyloid beta-protein (1-40)
Appendiceal Neoplasms

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