Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression

Arthritis and Rheumatism
Esperanza NaredoManuel Crespo

Abstract

To evaluate the sensitivity to change of power Doppler ultrasound (PDUS) assessment of joint inflammation and the predictive value of PDUS parameters in disease activity and radiologic outcome in patients with early rheumatoid arthritis (RA). Forty-two patients with early RA who started therapy with disease-modifying antirheumatic drugs underwent blinded sequential clinical, laboratory, and ultrasound assessment at baseline, 3 months, 6 months, and 1 year and radiographic assessment at baseline and 1 year. For each patient, 28-joint Disease Activity Score (DAS28) was recorded at each visit. The presence of synovitis was investigated in 28 joints using gray-scale ultrasonography and intraarticular power Doppler signal. Active synovitis was defined as intraarticular synovitis detected with power Doppler signal. The ultrasound joint count for active synovitis and an overall joint index for power Doppler signal were calculated. Sensitivity to change of PDUS variables was assessed by estimating the smallest detectable difference (SDD) from the intraobserver variability. The SDD for ultrasound joint count for active synovitis and ultrasound joint index for power Doppler signal was lower than mean changes from baseline to 3 months, 6 ...Continue Reading

References

Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Nov 1, 1995·Arthritis and Rheumatism·K GaffneyS Blades
Jun 1, 1995·Annals of the Rheumatic Diseases·O FitzGerald, B Bresnihan
Feb 1, 1997·Seminars in Ultrasound, CT, and MR·K J Murphy, J M Rubin
Jun 17, 1998·Arthritis and Rheumatism·A E Koch
Sep 19, 1998·Annals of the Rheumatic Diseases·W Grassi, C Cervini
Jan 9, 2004·The British Journal of Radiology·J TehE G McNally
Mar 17, 2004·Annals of the Rheumatic Diseases·R J WakefieldP Emery
Apr 23, 2004·Current Opinion in Rheumatology·Mikkel Østergaard, Charlotte Wiell
Jul 14, 2004·Annals of the Rheumatic Diseases·W A SchmidtE Gromnica-Ihle
May 10, 2005·Arthritis and Rheumatism·Thomas Pap, Oliver Distler

❮ Previous
Next ❯

Citations

Mar 5, 2013·Zeitschrift für Rheumatologie·W Hartung, W A Schmidt
May 24, 2013·Clinical Rheumatology·Rafael Mendonça da Silva ChakrJoão Carlos Tavares Brenol
Jun 5, 2013·Best Practice & Research. Clinical Rheumatology·Annamaria IagnoccoJohannes W J Bijlsma
Dec 10, 2013·Best Practice & Research. Clinical Rheumatology·Fiona M McQueen
Jul 29, 2009·Nature Reviews. Rheumatology·Alla SkapenkoHendrik Schulze-Koops
Nov 11, 2009·Nature Reviews. Rheumatology·Andrew K Brown
Jul 14, 2011·Nature Reviews. Rheumatology·Michael SchirmerChristian Dejaco
Apr 30, 2009·Rheumatology·Patrick D W KielyPhilip G Conaghan
Jun 6, 2009·Rheumatology·Toby GarroodCostantino Pitzalis
Oct 8, 2009·Rheumatology·PierLuigi MacchioniCarlo Salvarani
Jan 19, 2012·Rheumatology·Ahmed S ZayatRichard J Wakefield
Jan 19, 2012·Rheumatology·Francesco PortaAnnamaria Iagnocco
Apr 15, 2009·Current Opinion in Rheumatology·Edward Keystone
Sep 18, 2012·Annals of the Rheumatic Diseases·Esperanza NaredoUNKNOWN OMERACT Ultrasound Task Force*
Aug 4, 2012·Therapeutic Advances in Musculoskeletal Disease·Serena BugattiCarlomaurizio Montecucco
Jun 7, 2013·PloS One·Evangelia ZampeliPetros P Sfikakis
Jan 20, 2009·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Kazuhiko Yamamoto
Sep 21, 2013·Rheumatology·Jun FukaeTakao Koike
Apr 10, 2014·Arthritis Research & Therapy·Kei IkedaHiroshi Nakajima
Mar 29, 2014·Postgraduate Medical Journal·Fiona M McQueen
Feb 19, 2014·Clinical Rheumatology·Marwin GutierrezWalter Grassi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.