Longitudinal pulmonary status of cystic fibrosis children with meconium ileus

Pediatric Pulmonology
Zhanhai LiPhilip M Farrell

Abstract

Although meconium ileus (MI) is the earliest manifestation of cystic fibrosis (CF), and is associated with poorer growth, the longitudinal pulmonary progression of CF children with MI is not clear. To test the hypothesis that MI is associated with worse pulmonary outcomes, we prospectively compared from diagnosis to 12 years of age 32 CF children with MI to 50 CF children without MI who were diagnosed during early infancy through neonatal screening. Pulmonary outcome measures included respiratory symptoms, respiratory infections, pathogens, antibiotic usage, hospitalizations, quantitative chest radiology, spirometry, and lung volume determinations. Obstructive lung disease was defined as percent predicted spirometry values below the lower limits of normal. Longitudinal analyses revealed no significant differences in cough, wheezing, respiratory infections, prevalence of and median times to acquisition of Pseudomonas aeruginosa or Staphylococcus aureus, antibiotic usage, and chest radiograph scores between the two groups. However, MI children showed significantly worse forced expiratory volume in 1 sec (FEV(1)), forced vital capacity (FVC), forced expiratory flow between 25-75% of FVC (FEF(25-75)), % predicted FEV(1), % predicte...Continue Reading

References

Feb 1, 1992·Annals of Surgery·C A Del PinH C Bishop
Jan 1, 1988·Pediatric Pulmonology·R S TepperM Cohen
Apr 1, 1972·Archives of Disease in Childhood·J F McPartlinV A Swain
Oct 1, 1983·Journal of Pediatric Surgery·H Shwachman
Sep 1, 1994·Current Problems in Surgery·M M Ziegler
Feb 1, 1993·Pediatric Pulmonology·X WangB G Ferris
Apr 9, 1998·Pediatrics·J R Fuchs, J C Langer
Jan 5, 2002·The European Respiratory Journal·A K EvansK O McKay
Jun 8, 2002·JAMA : the Journal of the American Medical Association·Susan E H WestPhilip M Farrell
Jul 16, 2002·American Journal of Epidemiology·Hui-Chuan LaiPhilip M Farrell
Aug 12, 2003·Pediatric Pulmonology·Philip M FarrellMark L Splaingard
Aug 15, 2003·American Journal of Respiratory and Critical Care Medicine·Philip M FarrellMark L Splaingard

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Citations

Jul 9, 2011·American Journal of Respiratory and Critical Care Medicine·Don B SandersPhilip M Farrell
Jun 1, 2013·The European Respiratory Journal·Margaret RosenfeldStephanie D Davis
Nov 23, 2013·Annals of the American Thoracic Society·Don B SandersPhilip M Farrell
Mar 9, 2011·Current Gastroenterology Reports·Hubert P J van der DoefRoderick H J Houwen
Dec 26, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Maria SianoValeria Raia
Apr 22, 2008·Clinical Biochemistry·Teresinha LealKevin W Southern
Jul 22, 2010·Pediatric Pulmonology·Matthias Kappler, Matthias Griese
Nov 17, 2009·Pediatric Pulmonology·Matthias KapplerMatthias Griese
Nov 21, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Aimee C WalshUNKNOWN participating CF centres of Brittany, France
Jun 5, 2016·Paediatric Respiratory Reviews·Sabariah Noor HarunStefanie Hennig
Oct 16, 2016·Pediatric Pulmonology·Joseph F LevyPhilip M Farrell
May 25, 2006·Current Opinion in Pediatrics·Bryan J Dicken, Moritz M Ziegler
Jul 31, 2010·Pediatric Pulmonology·Jo-Anne JohnsonRoger Buchdahl
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Kevin W SouthernA D Nagelkerke
Feb 6, 2020·Cold Spring Harbor Molecular Case Studies·Melissa A WilkElizabeth A Worthey
Apr 15, 2017·European Journal of Pediatrics·Artemis DoulgerakiAthanasios G Kaditis
Jul 30, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Rita PadoanUNKNOWN Meconium Ileus Project Study Group
Nov 2, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Su Min Joyce TanChee Y Ooi

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