Longitudinal Relationship between Interleukin-6 and Perceived Fatigability among well-functioning Adults in mid-to-late Life

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Amal A WanigatungaJennifer A Schrack

Abstract

Chronically elevated interleukin-6 (IL-6) levels contribute to fatigue and functional decline via multiple pathways that often lead to frailty. Lesser known is the contribution of IL-6 to fatigue in relation to a standardized workload (fatigability), a precursor to functional decline. Therefore, the purpose of this study was to examine the longitudinal relationship between IL-6 and fatigability. 985 participants from the Baltimore Longitudinal Study of Aging (mean age: 70+/-10 years) were evaluated every 1-4 years. IL-6 was measured in fasting serum samples at each visit and log-transformed for analyses. Perceived fatigability (PF) was defined as self-reported exertion (Rate of Perceived Exertion; RPE) after a 5-minute, 0.67 m/s, 0% grade treadmill walk. Continuous and categorical associations between IL-6 (baseline and repeated measures) and PF were assessed using generalized estimating equations, adjusting for demographics, behavioral factors, and comorbid conditions. In fully adjusted continuous models, 2-fold higher baseline IL-6 was associated with a 0.28 higher RPE (p=0.03). This relationship tended to remain constant annually (baseline log IL-6 by time interaction p=0.29). To provide clinical relevance, the sample median...Continue Reading

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Citations

Aug 15, 2019·Journal of the American Heart Association·Yujia QiaoJennifer A Schrack
Dec 13, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elizabeth A SalernoJennifer A Schrack
Jan 17, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jennifer A SchrackLuigi Ferrucci
Apr 4, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roland von KänelBrent T Mausbach
Jul 4, 2020·Journal of the American Geriatrics Society·Eleanor M SimonsickLuigi Ferrucci
Sep 17, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jennifer A SchrackNancy W Glynn
May 28, 2019·Obesity·Pablo Martinez-AmezcuaJennifer A Schrack
Sep 25, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cutter A LindberghJoel H Kramer

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