Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood.

PloS One
Hao MeiGerald S Berenson

Abstract

Genome-wide association studies (GWAS) have identified multiple common variants associated with body mass index (BMI). In this study, we tested 23 genotyped GWAS-significant SNPs (p-value<5*10-8) for longitudinal associations with BMI during childhood (3-17 years) and adulthood (18-45 years) for 658 subjects. We also proposed a heuristic forward search for the best joint effect model to explain the longitudinal BMI variation. After using false discovery rate (FDR) to adjust for multiple tests, childhood and adulthood BMI were found to be significantly associated with six SNPs each (q-value<0.05), with one SNP associated with both BMI measurements: KCTD15 rs29941 (q-value<7.6*10-4). These 12 SNPs are located at or near genes either expressed in the brain (BDNF, KCTD15, TMEM18, MTCH2, and FTO) or implicated in cell apoptosis and proliferation (FAIM2, MAP2K5, and TFAP2B). The longitudinal effects of FAIM2 rs7138803 on childhood BMI and MAP2K5 rs2241423 on adulthood BMI decreased as age increased (q-value<0.05). The FTO candidate SNPs, rs6499640 at the 5 '-end and rs1121980 and rs8050136 downstream, were associated with childhood and adulthood BMI, respectively, and the risk effects of rs6499640 and rs1121980 increased as birth wei...Continue Reading

References

Jul 1, 1980·Preventive Medicine·M H CriquiJ D Turner
Dec 1, 1995·The American Journal of the Medical Sciences·L S WebberG S Berenson
May 26, 1995·The Journal of Biological Chemistry·G ZhouJ E Dixon
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·N V SomiaI M Verma
Apr 15, 2000·Nature·P G Kopelman
Sep 21, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P G Kopelman
Jan 4, 2001·Journal of Dentistry·T OhoT Koga
Sep 21, 2002·Lancet·Cara B EbbelingDavid S Ludwig
Oct 31, 2002·Neoplasia : an International Journal for Oncology Research·Gil M YerushalmiIlan Tsarfaty
Feb 26, 2003·The American Journal of Clinical Nutrition·Atul SinghalAlan Lucas
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Sep 20, 2005·Lancet·Richard Barnett
Oct 4, 2005·Lancet·David W Haslam, W Philip T James
Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Yu-Fen LiFrank D Gilliland
Jul 11, 2006·The New England Journal of Medicine·W James Gauderman
Sep 20, 2006·Nature Reviews. Genetics·David J Balding
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
May 6, 2008·Nature Genetics·Ruth J F LoosKaren L Mohlke
Jun 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Jane WardleRobert Plomin
Dec 17, 2008·Nature Genetics·Cristen J WillerUNKNOWN Genetic Investigation of ANthropometric Traits Consortium
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
Apr 7, 2010·Pediatrics·Stephanie BroylesGerald S Berenson
Oct 1, 2010·The American Journal of Clinical Nutrition·Atul SinghalAlan Lucas
Oct 5, 2010·PLoS Genetics·Xuesen WuMomiao Xiong
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos

❮ Previous
Next ❯

Citations

Mar 22, 2014·PloS One·Bastian GreshakeJulia Reda
Nov 15, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S AslibekyanD K Arnett
Jul 31, 2012·Human Genetics·Hao MeiGerald S Berenson
Aug 9, 2013·BMC Cardiovascular Disorders·Cong LiFang Zheng
Sep 9, 2016·Indian Journal of Clinical Biochemistry : IJCB·Apurva SrivastavaBalraj Mittal
Jun 26, 2013·Obesity·Audrey C ChohStefan A Czerwinski
Apr 30, 2015·Journal of Medical Genetics·Anthony J FulfordBranwen J Hennig
Dec 28, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M GraffP Gordon-Larsen
Jan 28, 2017·Obesity·Veerle RottiersSergiy Libert
Sep 28, 2017·Brain and Behavior·Carmen Gamero-VillarroelGuillermo Gervasini
Dec 15, 2015·American Journal of Lifestyle Medicine·Craig A Johnston, Jennette P Moreno
Jan 10, 2020·European Journal of Preventive Cardiology·Sofia Perez-CalahorraMartín Laclaustra
Jun 23, 2018·Frontiers in Cardiovascular Medicine·Wolfgang Lieb, Ramachandran S Vasan
Nov 9, 2019·International Journal of Environmental Research and Public Health·Victoria Garfield
Apr 4, 2021·International Journal of Molecular Sciences·Augusto Anguita-RuizFrancisco Javier Ruiz-Ojeda
Jun 10, 2021·Journal of Animal Physiology and Animal Nutrition·Pan ZhangBo Zhang

❮ Previous
Next ❯

Software Mentioned

R package lme4
QUANTO

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.