Longitudinal shear waves for elastic characterization of tissues in optical coherence elastography

Biomedical Optics Express
Fernando ZvietcovichKevin J Parker

Abstract

In dynamic optical coherence elastography (OCE), surface acoustic waves are the predominant perturbations. They constrain the quantification of elastic modulus to the direction of wave propagation only along the surface of tissues, and disregard elasticity gradients along depth. Longitudinal shear waves (LSW), on the other hand, can be generated at the surface of the tissue and propagate through depth with desirable properties for OCE: (1) LSW travel at the shear wave speed and can discriminate elasticity gradients along depth, and (2) the displacement of LSW is longitudinally polarized along the direction of propagation; therefore, it can be measured by a phase-sensitive optical coherence tomography system. In this study, we explore the capabilities of LSW generated by a circular glass plate in contact with a sample using numerical simulations and tissue-mimicking phantom experiments. Results demonstrate the potential of LSW in detecting an elasticity gradient along axial and lateral directions simultaneously. Finally, LSW are used for the elastography of ex vivo mouse brain and demonstrate important implications in in vivo and in situ measurements of local elasticity changes in brain and how they might correlate with the onse...Continue Reading

References

May 9, 2000·Ultrasonic Imaging·L SandrinM Fink
Oct 16, 2007·Ultrasound in Medicine & Biology·Kenneth HoytKevin J Parker
Feb 9, 2008·Ultrasound in Medicine & Biology·Man ZhangKevin J Parker
Dec 2, 2010·Physics in Medicine and Biology·K J ParkerD J Rubens
May 14, 2011·Journal of Biomechanics·John ZhangLynne E Bilston
Jul 14, 2011·Journal of Magnetic Resonance Imaging : JMRI·Matthew C MurphyRichard L Ehman
May 26, 2012·Optics Letters·Chunhui LiR K Wang
Dec 12, 2012·Journal of Biomedical Optics·Ravi Kiran ManapuramKirill V Larin
Nov 21, 2014·Journal of Biophotonics·Shang Wang, Kirill V Larin
Jan 30, 2015·Journal of the Royal Society, Interface·Ahmed AbassKeith M Meek
Feb 24, 2015·The Journal of the Acoustical Society of America·S Catheline, N Benech
Nov 2, 2015·The Journal of the Acoustical Society of America·Edwin L Carstensen, Kevin J Parker
Dec 23, 2016·Scientific Reports·Łukasz AmbrozińskiMatthew O'Donnell
Jan 13, 2017·Physics in Medicine and Biology·Kevin J ParkerBenjamin Castaneda
Mar 9, 2017·Biomedical Optics Express·Kirill V Larin, David D Sampson
Mar 31, 2017·Journal of Biomedical Optics·Fernando ZvietcovichKevin J Parker
Jun 15, 2017·Applied Physics Letters·Jiang ZhuZhongping Chen
Dec 25, 2017·Journal of Biomedical Optics·Mitchell A KirbyMatthew O'Donnell
Nov 20, 2018·Nature Communications·Humberto MestreDouglas H Kelley
Dec 13, 2018·Frontiers in Neurology·Mathilde BigotSimon A Lambert
Mar 21, 2019·Biomedical Optics Express·Matt S HepburnBrendan F Kennedy

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Citations

Sep 20, 2019·Journal of Biomedical Optics·Mitchell A KirbyMatthew O'Donnell
Mar 14, 2020·Journal of Biophotonics·Duo ZhangZhihong Huang
Oct 28, 2019·Biomedical Optics Express·Kirill V LarinDavid D Sampson
Dec 8, 2020·Biomedical Optics Express·Paul BoernerKonstantin V Sokolov

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