Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Annals of Neurology
Marcello MocciaMAGNIMS Study Group

Abstract

Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but longitudinal assessments on magnetic resonance imaging using segmentation-based methods suffer from measurement variability, especially in multicenter studies. We compared the generalized boundary shift integral (GBSI), a registration-based method, with a standard segmentation-based method. Baseline and 1-year spinal cord 3-dimensional T1-weighted images (1mm isotropic) were obtained from 282 patients (52 clinically isolated syndrome [CIS], 196 relapsing-remitting MS [RRMS], 34 progressive MS [PMS]), and 82 controls from 8 MAGNIMS (Magnetic Resonance Imaging in Multiple Sclerosis) sites on multimanufacturer and multi-field-strength scans. Spinal Cord Toolbox was used for C2-5 segmentation and cross-sectional area (CSA) calculation. After cord straightening and registration, GBSI measured atrophy based on the probabilistic boundary-shift region of interest. CSA and GBSI percentage annual volume change was calculated. GBSI provided similar rates of atrophy, but reduced measurement variability compared to CSA in all MS subtypes (CIS: -0.95 ± 2.11% vs -1.19 ± 3.67%; RRMS: -1.74 ± 2.57% vs -1.74 ± 4.02%; PMS: -2.29 ± 2.40% vs -1.29 ± 3.20%) and heal...Continue Reading

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Citations

Mar 7, 2020·Expert Review of Neurotherapeutics·Maria A RoccaMassimo Filippi
Apr 21, 2020·Expert Review of Neurotherapeutics·Eleonora TavazziNiels Bergsland
Sep 24, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Alberto CalviFrederik Barkhof
Nov 19, 2020·Brain Sciences·Yongsheng ChenEvanthia Bernitsas
Dec 27, 2019·NeuroImage·Ferran PradosClaudia Wheeler-Kingshott
Mar 31, 2021·Medical Image Analysis·Charley GrosJulien Cohen-Adad
Oct 19, 2020·Revue neurologique·S LeguyA Kerbrat
Aug 18, 2021·Nature Protocols·Julien Cohen-AdadJunqian Xu
Oct 5, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Paola ValsasinaUNKNOWN MAGNIMS Study Group;

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