Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets

NeuroImage. Clinical
Carles FalconAlzheimer's Disease Neuroimaging Initiative

Abstract

Alzheimer's disease (AD) is characterized by an accumulation of β-amyloid (Aβ42) accompanied by brain atrophy and cognitive decline. Several recent studies have shown that Aβ42 accumulation is associated with gray matter (GM) changes prior to the development of cognitive impairment, in the so-called preclinical stage of the AD (pre-AD). It also has been proved that the GM atrophy profile is not linear, both in normal ageing but, especially, on AD. However, several other factors may influence this association and may have an impact on the generalization of results from different samples. In this work, we estimate differences in rates of GM volume change in cognitively healthy elders in association with baseline core cerebrospinal fluid (CSF) AD biomarkers, and assess to what these differences are sample dependent. We report the dependence of atrophy rates, measured in a two-year interval, on Aβ42, computed both over continuous and categorical values of Aβ42, at voxel-level (p < 0.001; k < 100) and corrected for sex, age and education. Analyses were performed jointly and separately, on two samples. The first sample was formed of 31 individuals (22 Ctrl and 9 pre-AD), aged 60-80 and recruited at the Hospital Clinic of Barcelona. T...Continue Reading

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Citations

Jan 28, 2020·Aging·Zhen SunUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 20, 2019·Alzheimer's Research & Therapy·Paula M PetroneUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 12, 2020·Journal of Alzheimer's Disease : JAD·Carles FalconJosé Luis Molinuevo
Oct 18, 2020·Brain : a Journal of Neurology·Niklas Mattsson-CarlgrenOskar Hansson
Nov 30, 2020·Annals of Clinical and Translational Neurology·Oskar HanssonNiklas Mattsson-Carlgren
Nov 21, 2020·International Journal of Molecular Sciences·Bin Zhou, Masanori Fukushima
Mar 23, 2021·Therapeutic Advances in Neurological Disorders·Michela LeocadiFederica Agosta
May 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Prajakta A DhageShidin Balakrishnan

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Methods Mentioned

BETA
ELISA

Software Mentioned

Dartel
AAL
Power

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