Longitudinal studies on the effect of hypertension on circadian hemodynamic and autonomic rhythms in telemetered rats

Life Sciences
Mahmoud M El-Mas, Abdel A Abdel-Rahman


This study dealt with the long-term effects of hypertension on circadian rhythms of hemodynamic and cardiovascular autonomic functions in radiotelemetered rats. Blood pressure (BP), heart rate (HR), spontaneous locomotor activity, and respiration.were monitored in spontaneously hypertensive rats (SHRs), a model of human hypertension, from 14 to 27 weeks of age and in Wistar-Kyoto rats (WKY) as controls. Cardiovascular autonomic changes were determined by time-domain analysis of the variability of BP (standard deviation of mean arterial pressure, SDMAP) and HR (standard deviation of R-R intervals, SDRR, and the root mean square of successive differences in R-R intervals, rMSSD). Compared with WKY rats, the 24-hr MAP and SDMAP were higher at week 14 in SHRs and showed stepwise increases over the study duration, suggesting progressive increases in vasomotor sympathetic activity in hypertensive rats. Also, higher SDRR, rMSSD, and activity and lower HR and respiration were demonstrated in SHRs. Normal circadian rhythms (higher dark-time values) of MAP, HR, SDMAP, and SDRR were evident in WKY rats at week 20 and continued thereafter. Compared with WKY rats, the circadian BP and HR patterns were abolished and inverted, respectively, i...Continue Reading


Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·B P BrockwayS H Azar
Jan 1, 1991·Chronobiology International·P Baumgart
Jan 1, 1986·Journal of Cardiovascular Pharmacology·C BorghiE Ambrosioni
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·D L ClementL Packet
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·N MinamiK Yoshinaga
Aug 1, 1986·Clinical and Experimental Pharmacology & Physiology·V EijzenbachC Borst
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·B FolkowN Sjöblom
Apr 1, 1983·Pflügers Archiv : European journal of physiology·J BenessianoR Saumont
Feb 1, 1994·Physiology & Behavior·B J JanssenW J Rietveld
May 1, 1994·American Heart Journal·P K SteinB M Conger
Jun 2, 1998·Clinical and Experimental Hypertension : CHE·N Japundzic-Zigon
Apr 15, 1999·Journal of the American Geriatrics Society·K KoharaK Hiwada
Oct 8, 1999·Chronobiology International·M H SmolenskyE Haus
Nov 18, 2000·Hypertension·G Mancia, G Parati
Jan 18, 2002·Journal of Applied Physiology·Ann CapleaDaniel Ely
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Jeffery M KramerTony G Waldrop
Mar 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Nov 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Terry B J KuoCheryl C H Yang

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