Longitudinal studies on the effect of hypertension on circadian hemodynamic and autonomic rhythms in telemetered rats

Life Sciences
Mahmoud M El-Mas, Abdel A Abdel-Rahman

Abstract

This study dealt with the long-term effects of hypertension on circadian rhythms of hemodynamic and cardiovascular autonomic functions in radiotelemetered rats. Blood pressure (BP), heart rate (HR), spontaneous locomotor activity, and respiration.were monitored in spontaneously hypertensive rats (SHRs), a model of human hypertension, from 14 to 27 weeks of age and in Wistar-Kyoto rats (WKY) as controls. Cardiovascular autonomic changes were determined by time-domain analysis of the variability of BP (standard deviation of mean arterial pressure, SDMAP) and HR (standard deviation of R-R intervals, SDRR, and the root mean square of successive differences in R-R intervals, rMSSD). Compared with WKY rats, the 24-hr MAP and SDMAP were higher at week 14 in SHRs and showed stepwise increases over the study duration, suggesting progressive increases in vasomotor sympathetic activity in hypertensive rats. Also, higher SDRR, rMSSD, and activity and lower HR and respiration were demonstrated in SHRs. Normal circadian rhythms (higher dark-time values) of MAP, HR, SDMAP, and SDRR were evident in WKY rats at week 20 and continued thereafter. Compared with WKY rats, the circadian BP and HR patterns were abolished and inverted, respectively, i...Continue Reading

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Citations

Feb 1, 2011·Cardiovascular Toxicology·Alex P CarllAimen K Farraj
Jun 27, 2009·Archives of Pharmacal Research·Chang-Yong ShinChang-Seon Myung
Nov 5, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christina M LambAimen K Farraj
Apr 7, 2007·Journal of Cardiovascular Pharmacology·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Jul 14, 2010·Journal of Hypertension·Joep H M van EschA H Jan Danser
May 15, 2013·Clinical and Experimental Pharmacology & Physiology·Cara M HildrethJacqueline K Phillips
Apr 10, 2010·American Journal of Respiratory Cell and Molecular Biology·Aimen K FarrajDaniel L Costa
Dec 22, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Marwa Y SallamMahmoud M El-Mas
Apr 19, 2005·Alcoholism, Clinical and Experimental Research·Mahmoud M El-Mas, Abdel A Abdel-Rahman
May 30, 2015·Journal of Diabetes Science and Technology·Robert BrockwayTamer Coskun
Feb 23, 2019·Clinical and Experimental Pharmacology & Physiology·Tomas Baka, Fedor Simko

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