Longitudinal study of functional spinal alpha motor neuron loss in amyotrophic lateral sclerosis

Muscle & Nerve
Keisuke ArasakiM Tamaki

Abstract

Using a microstimulation technique for obtaining motor unit number estimates (MUNEs) of the hypothenar and extensor digitorum brevis (EDB) muscles, we performed a longitudinal study on the natural course of change in the clinical rating scale (Appel score) and of loss of functional spinal alpha motor neurons in amyotrophic lateral sclerosis. The Appel score increased to about 150% of normal at 12 months after onset, about 225% at 18 months after onset, and about 370% at 24 months after onset. By contrast, MUNEs decreased to about 27% of normal at 12 months after onset, about 12% at 18 months after onset, and about 5% at 24 months after onset. The relative merits of these different approaches in detecting changes in the disease process in its early phase are discussed.

References

Aug 1, 1996·Journal of the Neurological Sciences·M B Bromberg, W L Larson
Dec 5, 1998·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·A J McComas
May 30, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J M Shefner

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Citations

Aug 10, 2011·Neurology Research International·Mario Rafael PaganiOsvaldo Daniel Uchitel
Aug 16, 2006·Neuro-degenerative Diseases·F KamelD P Sandler
Jun 26, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Omid Rashidipour, K Ming Chan
Apr 23, 2004·Expert Opinion on Pharmacotherapy·Michael D WeissGregory T Carter
Jul 28, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christian Krarup
Nov 3, 2006·Brain Research Reviews·Gennadij Raivich, Milan Makwana
Aug 15, 2006·Journal of the Neurological Sciences·Keisuke ArasakiRyosuke Ushijima
Jan 21, 2006·Journal of the Neurological Sciences·Jasper R Daube
Apr 12, 2015·Cellular and Molecular Neurobiology·Meng LiYukun Li
Sep 5, 2014·Muscle & Nerve·Clifton L GoochJasper R Daube
Apr 24, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·F BaumannPamela A McCombe
Dec 3, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Colleen T IvesTimothy J Doherty
Oct 30, 2018·Muscle & Nerve·Christopher G WierStephen J Kolb
Apr 4, 2019·Frontiers in Neurology·Rangariroyashe Hannah ChipikaPeter Bede

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Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

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