Longitudinal study of gastroesophageal reflux and erosive tooth wear

BMC Gastroenterology
Clive H Wilder-SmithAdrian Lussi

Abstract

Approximately 60% of patients presenting to dentists with erosive tooth wear have significant gastroesophageal reflux (GERD), despite minor reflux symptoms. No longitudinal studies of reflux-associated erosive tooth wear and of reflux characteristics have been reported to date. The aim of this study was to characterize the longitudinal course of GERD and of associated erosive tooth wear, as well as factors predictive of its progression, in a large group of patients. Seventy-two patients presenting to dentists with clinically significant erosive tooth wear and increased esophageal acid exposure by 24-h multichannel intraluminal pH-impedance measurement (MII-pH) were re-assessed clinically and by MII-pH after 1 year treatment with esomeprazole 20 mg twice-daily. Predictive factors for erosive tooth wear were assessed by logistic regression. At follow-up, no further progression in erosive tooth wear was observed in 53 (74%) of patients. The percentage of time with a pH < 4, the number of acid reflux episodes and the percentage of proximal esophageal reflux off-PPI did not change significantly after one year, but the number of weakly acidic reflux episodes decreased significantly in the large subgroup without progression. None of t...Continue Reading

References

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Apr 30, 2015·United European Gastroenterology Journal·Clive H Wilder-SmithAdrian Lussi

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Citations

Jul 20, 2019·Expert Review of Gastroenterology & Hepatology·Matteo GhisaEdoardo Savarino
Feb 28, 2020·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Kimber Wakefield MacGibbon
Oct 28, 2019·Clinical Oral Investigations·Yousaf KamalEduardo Bernabé
May 28, 2020·Journal of Dental Education·Sercan AkyalcinLarisa Kure
Apr 25, 2018·Orphanet Journal of Rare Diseases·Ronnaug SaevesHilde Nordgarden
Aug 5, 2020·Journal of Dentistry·Stavroula MichouAna R Benetti
Feb 26, 2021·Biomaterial Investigations in Dentistry·Madalena Belmar da CostaAna Mano Azul

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