Longitudinal study of immune response to Pseudomonas aeruginosa antigens in cystic fibrosis.

Infection and Immunity
G Döring, N Høiby

Abstract

During a 10-year period, the clinical states of 10 cystic fibrosis patients were evaluated on the basis of monthly measurement of lung function and weight; serum antibody titers to alkaline protease and elastase and the number of precipitins to Pseudomonas aeruginosa standard antigen were determined by radioimmunoassay and crossed immunoelectrophoresis. Alkaline protease and elastase concentrations of the P. aeruginosa strains from the patients were measured in vitro. The immune response increased in nearly all patients after the onset of chronic P. aeruginosa lung infection over years, suggesting unimpaired production of these antigens during P. aeruginosa lung infection, whereas the clinical states declined. The mean time for immune response was 15 months for alkaline protease, 11 months for elastase, and 6 months for standard antigen.

References

Mar 1, 1979·The Journal of Infectious Diseases·T J MarrieJ W Costerton
Oct 1, 1972·Infection and Immunity·R G Doggett, G M Harrison
Nov 1, 1969·Applied Microbiology·R G Doggett
Mar 1, 1970·The Journal of Infectious Diseases·E DiazE Neter
Apr 1, 1983·The Journal of Infectious Diseases·G DöringA Hofmann
May 1, 1981·Infection and Immunity·L L Blackwood, J E Pennington
Jan 31, 1980·The New England Journal of Medicine·W J MatthewsH R Colten
Jun 1, 1971·Infection and Immunity·S Schwarzmann, J R Boring

❮ Previous
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Citations

Jun 3, 1985·Klinische Wochenschrift·U WinklerK E Jäger
Sep 1, 1993·The American Review of Respiratory Disease·A Buret, A W Cripps
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·M TamM M Stevenson
Oct 14, 2003·American Journal of Respiratory and Critical Care Medicine·Ronald L GibsonBonnie W Ramsey
Apr 21, 2007·Journal of Medical Microbiology·Abbie M WeisnerTyrone L Pitt
Mar 3, 2020·Frontiers in Immunology·Michael SörensenAlexander H Dalpke
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·B Przyklenk, A Bauernfeind
Oct 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·G DöringK Botzenhart
Oct 21, 2006·Current Opinion in Pulmonary Medicine·Felix Ratjen
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·S Suter
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Fadie T ColemanGerald B Pier
Nov 1, 1986·Archives of Disease in Childhood·M M BrettJ M Littlewood
Apr 25, 2000·Journal of Pediatric Gastroenterology and Nutrition·N R IsraelB D Gold
Jul 25, 2007·Pediatric Pulmonology·Miriam M TreggiariBonnie Ramsey
Apr 5, 2002·Clinical Microbiology Reviews·Jeffrey B LyczakGerald B Pier
Jan 1, 1989·Pediatric Pulmonology·G SteinkampH von der Hardt
Jan 1, 1990·Pediatric Pulmonology·M S Zach
May 2, 2015·The European Respiratory Journal·Tavs QvistNiels Høiby
Jun 29, 2010·FEMS Immunology and Medical Microbiology·Peter Østrup JensenClaus Moser
Apr 14, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Claus MoserPeter Østrup Jensen
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Walid A LotfyEhab R El-Helow
Nov 9, 2018·The Journal of Pharmacy and Pharmacology·Michaela EisenhardtFrank Runkel
Sep 19, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·G TaccettiI Sermet-Gaudelus
Sep 3, 1999·Journal of the Royal Society of Medicine·I M Balfour-Lynn
Mar 12, 2021·Frontiers in Immunology·Claus MoserTim Tolker-Nielsen
Mar 31, 2021·Immunity, Inflammation and Disease·Laurence S HanssensGeorges J Casimir

❮ Previous
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