Longitudinal Study of Mammographic Density Measures That Predict Breast Cancer Risk

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Kavitha KrishnanJohn L Hopper

Abstract

Background: After adjusting for age and body mass index (BMI), mammographic measures-dense area (DA), percent dense area (PDA), and nondense area (NDA)-are associated with breast cancer risk. Our aim was to use longitudinal data to estimate the extent to which these risk-predicting measures track over time.Methods:We collected 4,320 mammograms (age range, 24-83 years) from 970 women in the Melbourne Collaborative Cohort Study and the Australian Breast Cancer Family Registry. Women had on average 4.5 mammograms (range, 1-14). DA, PDA, and NDA were measured using the Cumulus software and normalized using the Box-Cox method. Correlations in the normalized risk-predicting measures over time intervals of different lengths were estimated using nonlinear mixed-effects modeling of Gompertz curves.Results:Mean normalized DA and PDA were constant with age to the early 40s, decreased over the next two decades, and were almost constant from the mid-60s onward. Mean normalized NDA increased nonlinearly with age. After adjusting for age and BMI, the within-woman correlation estimates for normalized DA were 0.94, 0.93, 0.91, 0.91, and 0.91 for mammograms taken 2, 4, 6, 8, and 10 years apart, respectively. Similar correlations were estimated f...Continue Reading

Citations

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Feb 16, 2018·Climacteric : the Journal of the International Menopause Society·K E McLean, J Stone
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Dec 6, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bernard RosnerGraham A Colditz
Apr 4, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Parisa TehranifarMary Beth Terry
Dec 15, 2020·Seminars in Cell & Developmental Biology·Amita G GhadgeWendy V Ingman

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