Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma

The Journal of Clinical Endocrinology and Metabolism
Hermann L MüllerNiels Sörensen

Abstract

We analyzed whether childhood craniopharyngioma predisposes to obesity and growth impairment. Height/length, body mass index (BMI), and hypothalamic involvement were evaluated in 90 patients at standardized ages and time points before, after, and at the time of diagnosis. Relevant decreases in height sd score (SDS) started at 10-12 months of age and persisted until diagnosis of childhood craniopharyngioma. Relevant increases in BMI SDS were detectable between 4 and 5 yr of age. Postoperative BMI SDS (yr 1-6) had a weak positive correlation with BMI SDS at the time of diagnosis. In linear regression analysis, hypothalamic tumor involvement (P < 0.001), ponderal index at birth (P = 0.014), and BMI SDS at age 6-7 months (P = 0.029) and at age 5 yr (P < 0.001) had relevant and independent impacts on the development of obesity. Patients with hypothalamic involvement (n = 48) presented lower ponderal index and BMI SDS at birth and higher BMI SDS at the time of diagnosis (P < 0.001) as well as during annual follow-up (P < 0.001) compared with patients without hypothalamic involvement (n = 42). From childhood (3.5-4 yr) to the time of diagnosis, growth rates were reduced for patients with hypothalamic tumor involvement. Patients withou...Continue Reading

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Citations

Aug 3, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hermann L MüllerNiels Sörensen
Aug 3, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·John A Kalapurakal
Jul 28, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Isil Halac, Donald Zimmerman
Dec 6, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matthieu VinchonPatrick Dhellemmes
Jun 18, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Maria A KalinaMarek Mandera
Mar 17, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matthieu VinchonIsabelle Delestret
Apr 6, 2006·Cancer Causes & Control : CCC·Hermann L MüllerNiels Sörensen
Jun 9, 2012·Pituitary·Hermann L Müller
Sep 11, 2012·Pituitary·Eva Marie ErfurthSigridur Bara Fjalldal
Aug 6, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·A IannalfiF Saran
Sep 24, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Songtao QiGuanglong Huang
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Sep 26, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Madhusmita Misra, Lynne L Levitsky
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