Longitudinal study on mutation profiles of core promoter and precore regions of the hepatitis B virus genome in children

Pediatric Research
Yen-Hsuan NiDaw-Jen Tsuei

Abstract

Precore nucleotide 1896 and core promoter mutations may account for hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B virus (HBV) infection, yet the mutational profiles of the core promoter are largely unknown in children. An age-matched, case-control study enrolled 110 chronic HBV-infected children, including 55 HBeAg seroconverters and 55 nonseroconverters. Precore and core promoter genes of HBV were sequenced and the serum viral genomes were genotyped from three serial serum samples of the seroconverters and from one serum sample of the nonseroconverters. Higher frequency of A1775G and G1799C mutation rates and lower frequency of A1752G mutation rate were found in the seroconverters. Precore 1896 mutation appeared more in seroconverters than in nonseroconverters (45.5% versus 10.9%; p < 0.001). 1762 + 1764 mutation rates were not different between the seroconverters (9.1%) and the nonseroconverters (5.5%). Genotype B was the major type. Genotype C was associated with core promoter 1762 + 1764 mutations in the seroconverter group (p = 0.023). The conclusions of this study include the following: 1) mutations of core promoter at nucleotide position 1752, 1775, and 1799 have significant correlations with HBeAg ...Continue Reading

References

Jan 1, 1992·The Journal of Infectious Diseases·W F CarmanH C Thomas
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P I LeeD S Chen
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D R MilichA McLachlan
May 18, 1989·Nature·S Kwok, R Higuchi
Jun 1, 1997·The Journal of General Virology·K Kidd-LjunggrenA H Kidd
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L ChanA S Lok
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M FriedtS Wirth
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Man-Fung YuenChing Lung Lai

❮ Previous
Next ❯

Citations

Sep 29, 2006·Indian Journal of Pediatrics·Mei-Hwei Chang
Oct 10, 2009·Pediatric Research·Hsiang-Po HuangMei-Hwei Chang
Sep 3, 2010·Journal of Gastroenterology·Yen-Hsuan Ni
Jul 21, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xue-Yan WangZhong-Liao Fang
Jul 10, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Chien-Hung ChenChi-Sin Changchien
Nov 21, 2017·The Journal of Infectious Diseases·Hung-Chih YangChun-Jen Liu
Apr 7, 2011·Journal of Korean Medical Science·Hyun Sik KangByung-Cheol Song
May 3, 2005·Current Opinion in Infectious Diseases·Pier-Angelo TovoAntonia Versace
Oct 31, 2019·Expert Review of Gastroenterology & Hepatology·Ming-Wei Lai, Mei-Hwei Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.