Longitudinal study to assess impact of smoking at diagnosis and quitting on 1-year survival for people with non-small cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Rachel E GemineLungCast Investigators

Abstract

To update the prevalence of smoking in people as they were diagnosed with non-small cell lung cancer (NSCLC) and to see whether smoking status at baseline and quitting are independently associated with 1-year survival. A real-world cohort study following patients from diagnosis for up to 1 year or until death. UK multi-centre study (28 sites) based in secondary and primary care. 1124 patients with newly diagnosed NSCLC between 2010-2016. Smoking status was validated at diagnosis and at every routine and emergency hospital visit. Cancer treatments were offered according to local multi-disciplinary team decisions following UK guidelines and smoking cessation treatments offered according to local practice /availability. Survival analysis and Cox Proportional Hazards Modelling examined the associations of a) smoking at baseline and b) quitting smoking, on survival at 1 year. 77% of never smokers, 60% of ex-smokers and 57% of current smokers, were alive at 1 year (p = 0.01). After adjusting for age, stage, EGOG, surgery and gender, ex smokers (adjusted HR 1.96, 95% CI 1.16-2.31) and current smokers (aHR 2.04, 1.19-3.48) were both more likely to die within one year. 23% of smokers with NSCLC quit within 3 months of diagnosis. At 1 ye...Continue Reading

Citations

Jun 12, 2019·CA: a Cancer Journal for Clinicians·Kimberly D MillerRebecca L Siegel
Apr 23, 2020·Frontiers in Pharmacology·Preshita DesaiSunil Prabhu
Mar 23, 2021·ERJ Open Research·Diana A van der PlaatOrianne Dumas

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