Longitudinal tendon healing assessed with multi-modality advanced imaging and tissue analysis.

Equine Veterinary Journal
Sherry A JohnsonDavid D Frisbie

Abstract

The range of diagnostic modalities available to evaluate superficial digital flexor tendon (SDFT) injury includes magnetic resonance imaging (MRI), computed tomography (CT) and ultrasonography (US). Direct, comprehensive comparison of multi-modality imaging characteristics to end-point data has not previously been performed using a model of tendinopathy but is required to obtain a better understanding of each modality's diagnostic capabilities. To compare CT, MRI and US evaluation to outcome measures for histologic, biochemical and biomechanical parameters using an equine surgical model of tendinopathy. Controlled experiment. Lesions were surgically created in both forelimb SDFTs of eight horses and imaged using MRI, CT and US at seven time points over 12 months. Imaging characteristics were then correlated to end point histologic, biochemical and biomechanical data using lasso regression. Longitudinal lesion size was compared between imaging modalities. Lesion to tendon isoattenuation on CT evaluation correlated with the greatest levels of aggrecan deposition. A significant correlation between cellular density and percentage of tendon involvement on the T2-weighted sequence and signal intensity on the proton density fat satura...Continue Reading

References

Oct 1, 1988·Analytical Biochemistry·Y J KimA J Grodzinsky
Apr 1, 1997·Scandinavian Journal of Medicine & Science in Sports·M JärvinenW Leadbetter
May 4, 1999·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·J T van SchieP R van Weeren
Feb 24, 2000·American Journal of Veterinary Research·H T van Schie, E M Bakker
Feb 24, 2000·American Journal of Veterinary Research·H T van SchieP R van Weeren
Jan 31, 2002·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Michael MöllerJon Karlsson
May 3, 2005·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Mads KristoffersenHåkan Alfredson
Sep 1, 2005·The Veterinary Journal·B A Dowling, A J Dart
Oct 19, 2005·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Valeria BusoniRobert F Dondelinger
Sep 19, 2006·European Journal of Radiology·Peter Dawson
Jan 24, 2007·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Sarah M PuchalskiErik R Wisner
Jul 3, 2008·American Journal of Veterinary Research·Alan J NixonDaniel L Ward
Sep 26, 2008·Statistics in Medicine·Lloyd J EdwardsOliver Schabenberger
Mar 13, 2009·The American Journal of Sports Medicine·Marieke de MosGerjo J V M van Osch
Jun 11, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Sarah M PuchalskiErik R Wisner
Aug 29, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gerco BoschP René van Weeren
May 18, 2010·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Michael SchrammeRaphael Labens
May 13, 2011·Ecology·David I Warton, Francis K C Hui
Jul 21, 2012·The Journal of Veterinary Medical Science·Daiki MurataMakoto Fujiki
Nov 28, 2012·The Veterinary Clinics of North America. Equine Practice·Travis C Saveraid, Carter E Judy
Oct 8, 2013·Journal of the American Veterinary Medical Association·Tyler E TiptonD Reese Hand
Jun 19, 2014·Prevention Science : the Official Journal of the Society for Prevention Research·Donald Hedeker
Mar 20, 2019·Journal of the American Veterinary Medical Association·Andrew R E JonesMacarena G Sanz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.